Reactome | ADP [nucleoplasm]

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ADP [nucleoplasm]

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compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-DRE-5252025] HSPA1A:ADP [nucleoplasm] - Danio rerio [Complex:R-XTR-5252089] HSPA12A:ADP [nucleoplasm] - Xenopus tropicalis [Complex:R-MMU-5357523] MSH2:MSH6:ADP [nucleoplasm] - Mus musculus
consumedByEvent	[Reaction:R-SPO-5444511] Formation of MSH2:MSH3 Complex - Schizosaccharomyces pombe [Reaction:R-RNO-5444511] Formation of MSH2:MSH3 Complex - Rattus norvegicus [Reaction:R-SCE-5444516] Formation of MSH2:MSH6 Complex - Saccharomyces cerevisiae [Reaction:R-SCE-5444511] Formation of MSH2:MSH3 Complex - Saccharomyces cerevisiae [Reaction:R-CEL-5444516] Formation of MSH2:MSH6 Complex - Caenorhabditis elegans [Reaction:R-DME-5444516] Formation of MSH2:MSH6 Complex - Drosophila melanogaster [Reaction:R-RNO-5444516] Formation of MSH2:MSH6 Complex - Rattus norvegicus [Reaction:R-SPO-5444516] Formation of MSH2:MSH6 Complex - Schizosaccharomyces pombe [Reaction:R-DDI-5444516] Formation of MSH2:MSH6 Complex - Dictyostelium discoideum [Reaction:R-DDI-5444511] Formation of MSH2:MSH3 Complex - Dictyostelium discoideum [Reaction:R-CFA-5444516] Formation of MSH2:MSH6 Complex - Canis familiaris [Reaction:R-DRE-5444511] Formation of MSH2:MSH3 Complex - Danio rerio [Reaction:R-CFA-5444511] Formation of MSH2:MSH3 Complex - Canis familiaris [Reaction:R-DRE-5444516] Formation of MSH2:MSH6 Complex - Danio rerio [Reaction:R-SSC-5444516] Formation of MSH2:MSH6 Complex - Sus scrofa [Reaction:R-HSA-5444516] Formation of MSH2:MSH6 Complex - Homo sapiens [Reaction:R-XTR-5444511] Formation of MSH2:MSH3 Complex - Xenopus tropicalis [Reaction:R-SSC-5444511] Formation of MSH2:MSH3 Complex - Sus scrofa [Reaction:R-XTR-5444516] Formation of MSH2:MSH6 Complex - Xenopus tropicalis [Reaction:R-GGA-5444511] Formation of MSH2:MSH3 Complex - Gallus gallus [Reaction:R-PFA-5444516] Formation of MSH2:MSH6 Complex - Plasmodium falciparum [Reaction:R-MMU-5444516] Formation of MSH2:MSH6 Complex - Mus musculus [Reaction:R-MMU-5444511] Formation of MSH2:MSH3 Complex - Mus musculus [Reaction:R-BTA-5444516] Formation of MSH2:MSH6 Complex - Bos taurus [Reaction:R-HSA-5444511] Formation of MSH2:MSH3 Complex - Homo sapiens [Reaction:R-BTA-5444511] Formation of MSH2:MSH3 Complex - Bos taurus
created	[InstanceEdit:113517] Schmidt, EE, 2004-06-09 05:19:12
crossReference	[DatabaseIdentifier:29371] COMPOUND:C00008
dbId	113582
displayName	ADP [nucleoplasm]
inDisease	false
memberOf	[DefinedSet:R-ALL-6788807] (d)NDPs [nucleoplasm]
modified	[InstanceEdit:9655248] D'Eustachio, Peter, 2019-07-23
name	ADP Adenosine 5'-diphosphate ADP(3-)
producedByEvent	[Reaction:R-SPO-5693540] MRN activates ATM - Schizosaccharomyces pombe [Reaction:R-GGA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Gallus gallus [Reaction:R-HSA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Homo sapiens [Reaction:R-HSA-5685156] ATR phosphorylates RPA2 - Homo sapiens [Reaction:R-MMU-168136] Activated JNKs phosphorylate c-JUN - Mus musculus [Reaction:R-BTA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Bos taurus [Reaction:R-RNO-5693536] ATM phosphorylates MDC1 - Rattus norvegicus [Reaction:R-MMU-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Mus musculus [Reaction:R-HSA-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Homo sapiens [Reaction:R-XTR-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Xenopus tropicalis [Reaction:R-XTR-6805640] AKT phosphorylates KAT6A - Xenopus tropicalis [Reaction:R-RNO-5684887] Activation of CHEK1 at resected DNA DSBs - Rattus norvegicus [Reaction:R-DDI-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Dictyostelium discoideum [Reaction:R-XTR-5686578] Activated ATM phosphorylates ABL1 - Xenopus tropicalis [Reaction:R-DRE-6805276] CDK5 phosphorylates TP53 - Danio rerio [Reaction:R-SSC-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Sus scrofa [Reaction:R-HSA-5682026] MRN bound to shortened telomeres activates ATM - Homo sapiens [Reaction:R-DRE-168136] Activated JNKs phosphorylate c-JUN - Danio rerio [Reaction:R-RNO-6805479] TP53RK phosphorylates TP53 - Rattus norvegicus [Reaction:R-SSC-5684096] CDK2 phosphorylates RBBP8 - Sus scrofa [Reaction:R-XTR-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Xenopus tropicalis [Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM - Homo sapiens [Reaction:R-DRE-5683930] WICH phosphorylates H2AFX on Y142 - Danio rerio [Reaction:R-XTR-5685156] ATR phosphorylates RPA2 - Xenopus tropicalis [Reaction:R-DME-6805399] TAF1 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-CFA-448955] Phosphorylation of MEF2 proteins by p38 - Canis familiaris [Reaction:R-DRE-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Danio rerio [Reaction:R-SSC-349455] Phosphorylation of MDM4 by ATM - Sus scrofa [Reaction:R-DME-5693598] ATM phosphorylates NBN - Drosophila melanogaster [Reaction:R-SSC-5682026] MRN bound to shortened telomeres activates ATM - Sus scrofa [Reaction:R-HSA-5686578] Activated ATM phosphorylates ABL1 - Homo sapiens [Reaction:R-DRE-448955] Phosphorylation of MEF2 proteins by p38 - Danio rerio [Reaction:R-CFA-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Canis familiaris [Reaction:R-CFA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Canis familiaris [Reaction:R-SSC-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Sus scrofa [Reaction:R-GGA-5686578] Activated ATM phosphorylates ABL1 - Gallus gallus [BlackBoxEvent:R-RNO-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Rattus norvegicus [Reaction:R-MMU-5685156] ATR phosphorylates RPA2 - Mus musculus [Reaction:R-PFA-5683792] p-T68-CHEK2 autophosphorylates - Plasmodium falciparum [Reaction:R-SSC-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Sus scrofa [Reaction:R-GGA-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Gallus gallus [Reaction:R-XTR-6802973] PLK3 phosphorylates CDC25C - Xenopus tropicalis [Reaction:R-DME-5693540] MRN activates ATM - Drosophila melanogaster [Reaction:R-HSA-5685230] CHEK1 phosphorylates RAD51 - Homo sapiens [Reaction:R-MMU-448953] Phosphorylation of E47 by p38 MAPK - Mus musculus [Reaction:R-DME-6805276] CDK5 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-CFA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Canis familiaris [Reaction:R-BTA-3371567] DBC1 is phosphorylated by ATM/ART - Bos taurus [Reaction:R-BTA-6805276] CDK5 phosphorylates TP53 - Bos taurus [Reaction:R-SSC-6805126] AURKB phosphorylates TP53 - Sus scrofa [Reaction:R-DME-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Drosophila melanogaster [Reaction:R-XTR-6805126] AURKB phosphorylates TP53 - Xenopus tropicalis [Reaction:R-SSC-3222020] NUAK1 phosphorylates TP53 - Sus scrofa [Reaction:R-RNO-5685156] ATR phosphorylates RPA2 - Rattus norvegicus [Reaction:R-MMU-5683801] CHEK2 phosphorylates BRCA1 - Mus musculus [Reaction:R-GGA-5683801] CHEK2 phosphorylates BRCA1 - Gallus gallus [Reaction:R-SPO-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Schizosaccharomyces pombe [Reaction:R-DME-6805479] TP53RK phosphorylates TP53 - Drosophila melanogaster [Reaction:R-CFA-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Canis familiaris [Reaction:R-DRE-6805640] AKT phosphorylates KAT6A - Danio rerio [Reaction:R-GGA-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Gallus gallus [Reaction:R-GGA-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Gallus gallus [Reaction:R-MMU-5684887] Activation of CHEK1 at resected DNA DSBs - Mus musculus [Reaction:R-XTR-176298] Activation of claspin - Xenopus tropicalis [Reaction:R-HSA-6805640] AKT phosphorylates KAT6A - Homo sapiens [Reaction:R-CFA-5684096] CDK2 phosphorylates RBBP8 - Canis familiaris [Reaction:R-BTA-8848975] PTK6 phosphorylates KHDRBS1 - Bos taurus [Reaction:R-SCE-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Saccharomyces cerevisiae [Reaction:R-SSC-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Sus scrofa [Reaction:R-CEL-5683792] p-T68-CHEK2 autophosphorylates - Caenorhabditis elegans [Reaction:R-CFA-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Canis familiaris [Reaction:R-DDI-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Dictyostelium discoideum [Reaction:R-RNO-3222006] STK11 (LKB1) phosphorylates NUAK1 - Rattus norvegicus [Reaction:R-DME-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Drosophila melanogaster [Reaction:R-CFA-5682598] ATM phosphorylates HERC2 - Canis familiaris [Reaction:R-PFA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Plasmodium falciparum [Reaction:R-RNO-6805059] CK2:FACT phosphorylates TP53 - Rattus norvegicus [Reaction:R-MMU-6805126] AURKB phosphorylates TP53 - Mus musculus [Reaction:R-DRE-5685230] CHEK1 phosphorylates RAD51 - Danio rerio [Reaction:R-GGA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus [Reaction:R-CFA-349426] Phosphorylation of MDM4 by CHEK2 - Canis familiaris [Reaction:R-DME-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Drosophila melanogaster [Reaction:R-CFA-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Canis familiaris [Reaction:R-HSA-5693598] ATM phosphorylates NBN - Homo sapiens [Reaction:R-BTA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Bos taurus [Reaction:R-RNO-8878054] HIPK2 phosphorylates RUNX1 - Rattus norvegicus [Reaction:R-XTR-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Xenopus tropicalis [Reaction:R-HSA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Homo sapiens [Reaction:R-RNO-6798372] ATM phosphorylates DYRK2 - Rattus norvegicus [Reaction:R-SSC-5686578] Activated ATM phosphorylates ABL1 - Sus scrofa [Reaction:R-RNO-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Rattus norvegicus [Reaction:R-CFA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Canis familiaris [Reaction:R-DME-6805640] AKT phosphorylates KAT6A - Drosophila melanogaster [Reaction:R-RNO-6805470] AMPK phosphorylates TP53 - Rattus norvegicus [Reaction:R-RNO-5683792] p-T68-CHEK2 autophosphorylates - Rattus norvegicus [Reaction:R-XTR-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Xenopus tropicalis [Reaction:R-DRE-5682598] ATM phosphorylates HERC2 - Danio rerio [Reaction:R-RNO-5195402] CDK1 phosphorylates LPIN - Rattus norvegicus [Reaction:R-SPO-5683792] p-T68-CHEK2 autophosphorylates - Schizosaccharomyces pombe [Reaction:R-XTR-6805059] CK2:FACT phosphorylates TP53 - Xenopus tropicalis [Reaction:R-DRE-5683964] ATM phosphorylates EYA1-4 - Danio rerio [Reaction:R-SPO-5693598] ATM phosphorylates NBN - Schizosaccharomyces pombe [Reaction:R-MMU-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Mus musculus [Reaction:R-DRE-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Danio rerio [Reaction:R-HSA-69754] Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes - Homo sapiens [Reaction:R-BTA-6799097] ATM phosphorylates ZNF420 - Bos taurus [Reaction:R-XTR-5682026] MRN bound to shortened telomeres activates ATM - Xenopus tropicalis [Reaction:R-RNO-5693598] ATM phosphorylates NBN - Rattus norvegicus [Reaction:R-XTR-6805470] AMPK phosphorylates TP53 - Xenopus tropicalis [Reaction:R-SSC-6805059] CK2:FACT phosphorylates TP53 - Sus scrofa [Reaction:R-CEL-5693540] MRN activates ATM - Caenorhabditis elegans [Reaction:R-SCE-168136] Activated JNKs phosphorylate c-JUN - Saccharomyces cerevisiae [Reaction:R-PFA-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Plasmodium falciparum [Reaction:R-BTA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Bos taurus [Reaction:R-HSA-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Homo sapiens [Reaction:R-SSC-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Sus scrofa [Reaction:R-SPO-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Schizosaccharomyces pombe [Reaction:R-CEL-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Caenorhabditis elegans [Reaction:R-MMU-5685230] CHEK1 phosphorylates RAD51 - Mus musculus [Reaction:R-DDI-3371567] DBC1 is phosphorylated by ATM/ART - Dictyostelium discoideum [Reaction:R-HSA-3371567] DBC1 is phosphorylated by ATM/ART - Homo sapiens [Reaction:R-SSC-5684887] Activation of CHEK1 at resected DNA DSBs - Sus scrofa [Reaction:R-CEL-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Caenorhabditis elegans [Reaction:R-CEL-5693598] ATM phosphorylates NBN - Caenorhabditis elegans [Reaction:R-CEL-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Caenorhabditis elegans [Reaction:R-HSA-8868666] CDK5:p25 phosphorylates JUN - Homo sapiens [Reaction:R-SSC-3371567] DBC1 is phosphorylated by ATM/ART - Sus scrofa [Reaction:R-RNO-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Rattus norvegicus [Reaction:R-MMU-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Mus musculus [Reaction:R-XTR-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Xenopus tropicalis [Reaction:R-HSA-8868344] CDK5:p25 phosphorylates lamin A - Homo sapiens [Reaction:R-SPO-6798372] ATM phosphorylates DYRK2 - Schizosaccharomyces pombe [Reaction:R-RNO-349426] Phosphorylation of MDM4 by CHEK2 - Rattus norvegicus [Reaction:R-XTR-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Xenopus tropicalis [Reaction:R-CFA-5685156] ATR phosphorylates RPA2 - Canis familiaris [Reaction:R-SSC-5683964] ATM phosphorylates EYA1-4 - Sus scrofa [Reaction:R-MMU-3222020] NUAK1 phosphorylates TP53 - Mus musculus [Reaction:R-BTA-8956659] ABL1 phosphorylates YAP1 - Bos taurus [Reaction:R-GGA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Gallus gallus [Reaction:R-HSA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Homo sapiens [Reaction:R-DME-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Drosophila melanogaster [Reaction:R-CFA-6798372] ATM phosphorylates DYRK2 - Canis familiaris [Reaction:R-SSC-5685156] ATR phosphorylates RPA2 - Sus scrofa [Reaction:R-CEL-5682026] MRN bound to shortened telomeres activates ATM - Caenorhabditis elegans [Reaction:R-BTA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Bos taurus [Reaction:R-DRE-3239014] MAPKAPK5 phosphorylates TP53 - Danio rerio [Reaction:R-XTR-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Xenopus tropicalis [Reaction:R-DRE-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Danio rerio [Reaction:R-CEL-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Caenorhabditis elegans [Reaction:R-GGA-4088134] PLK1 phosphorylates FOXM1 - Gallus gallus [Reaction:R-HSA-5683801] CHEK2 phosphorylates BRCA1 - Homo sapiens [Reaction:R-MMU-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Mus musculus [Reaction:R-XTR-5682598] ATM phosphorylates HERC2 - Xenopus tropicalis [Reaction:R-HSA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Homo sapiens [Reaction:R-SSC-8878054] HIPK2 phosphorylates RUNX1 - Sus scrofa [Reaction:R-CFA-6805640] AKT phosphorylates KAT6A - Canis familiaris [Reaction:R-BTA-5683930] WICH phosphorylates H2AFX on Y142 - Bos taurus [Reaction:R-CFA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Canis familiaris [Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-6799097] ATM phosphorylates ZNF420 - Homo sapiens [Reaction:R-SCE-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Saccharomyces cerevisiae [Reaction:R-BTA-6805399] TAF1 phosphorylates TP53 - Bos taurus [Reaction:R-DME-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Drosophila melanogaster [Reaction:R-DDI-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Dictyostelium discoideum [Reaction:R-HSA-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Homo sapiens [Reaction:R-GGA-217013] Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members - Gallus gallus [Reaction:R-MMU-1605475] Ampk phosphorylates Ppargc1a - Mus musculus [Reaction:R-DRE-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Danio rerio [Reaction:R-SSC-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Sus scrofa [Reaction:R-DRE-5683801] CHEK2 phosphorylates BRCA1 - Danio rerio [Reaction:R-CEL-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Caenorhabditis elegans [Reaction:R-GGA-6799097] ATM phosphorylates ZNF420 - Gallus gallus [Reaction:R-XTR-5693536] ATM phosphorylates MDC1 - Xenopus tropicalis [BlackBoxEvent:R-DRE-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Danio rerio [Reaction:R-DME-5682026] MRN bound to shortened telomeres activates ATM - Drosophila melanogaster [Reaction:R-DME-5683964] ATM phosphorylates EYA1-4 - Drosophila melanogaster [Reaction:R-MMU-6805479] TP53RK phosphorylates TP53 - Mus musculus [Reaction:R-HSA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Homo sapiens [Reaction:R-HSA-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Homo sapiens [Reaction:R-HSA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Homo sapiens [Reaction:R-MMU-349455] Phosphorylation of MDM4 by ATM - Mus musculus [Reaction:R-HSA-168136] Activated JNKs phosphorylate c-JUN - Homo sapiens [Reaction:R-DDI-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Dictyostelium discoideum [Reaction:R-GGA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Gallus gallus [Reaction:R-MMU-5683930] WICH phosphorylates H2AFX on Y142 - Mus musculus [Reaction:R-CEL-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Caenorhabditis elegans [Reaction:R-DME-6798372] ATM phosphorylates DYRK2 - Drosophila melanogaster [Reaction:R-RNO-211164] AKT phosphorylates FOXO1A - Rattus norvegicus [Reaction:R-XTR-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Xenopus tropicalis [Reaction:R-DME-8849463] PTK6 phosphorylates SFPQ - Drosophila melanogaster [Reaction:R-CEL-5683964] ATM phosphorylates EYA1-4 - Caenorhabditis elegans [Reaction:R-DRE-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Danio rerio [Reaction:R-DRE-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Danio rerio [Reaction:R-GGA-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Gallus gallus [Reaction:R-RNO-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Rattus norvegicus [Reaction:R-HSA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Homo sapiens [Reaction:R-XTR-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Xenopus tropicalis [Reaction:R-SPO-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Schizosaccharomyces pombe [Reaction:R-DME-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Drosophila melanogaster [Reaction:R-SPO-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Schizosaccharomyces pombe [Reaction:R-RNO-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Rattus norvegicus [Reaction:R-MMU-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Mus musculus [Reaction:R-RNO-5693540] MRN activates ATM - Rattus norvegicus [Reaction:R-DRE-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Danio rerio [Reaction:R-XTR-5684096] CDK2 phosphorylates RBBP8 - Xenopus tropicalis [Reaction:R-SPO-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Schizosaccharomyces pombe [Reaction:R-SSC-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Sus scrofa [Reaction:R-SSC-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Sus scrofa [Reaction:R-CEL-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Caenorhabditis elegans [Reaction:R-MMU-8849042] PTK6 phosphorylates KHDRBS3 - Mus musculus [Reaction:R-RNO-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Rattus norvegicus [Reaction:R-CFA-5684887] Activation of CHEK1 at resected DNA DSBs - Canis familiaris [Reaction:R-SSC-3222006] STK11 (LKB1) phosphorylates NUAK1 - Sus scrofa [Reaction:R-GGA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Gallus gallus [Reaction:R-RNO-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Rattus norvegicus [Reaction:R-CFA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Canis familiaris [Reaction:R-HSA-5686410] BLM mediates dissolution of double Holliday junction - Homo sapiens [Reaction:R-MMU-8868356] Cdk5:p25 phosphorylates lamin A - Mus musculus [Reaction:R-HSA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Homo sapiens [Reaction:R-MMU-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Mus musculus [Reaction:R-CFA-6802973] PLK3 phosphorylates CDC25C - Canis familiaris [Reaction:R-MMU-6805276] CDK5 phosphorylates TP53 - Mus musculus [Reaction:R-DME-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Drosophila melanogaster [Reaction:R-XTR-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Xenopus tropicalis [BlackBoxEvent:R-MMU-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Mus musculus [Reaction:R-SSC-5693598] ATM phosphorylates NBN - Sus scrofa [Reaction:R-SPO-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Schizosaccharomyces pombe [Reaction:R-DDI-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Dictyostelium discoideum [Reaction:R-GGA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Gallus gallus [Reaction:R-XTR-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Xenopus tropicalis [Reaction:R-XTR-176116] Recruitment and activation of Chk1 - Xenopus tropicalis [Reaction:R-RNO-6799097] ATM phosphorylates ZNF420 - Rattus norvegicus [Reaction:R-CFA-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Canis familiaris [Reaction:R-SSC-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Sus scrofa [Reaction:R-SPO-6802973] PLK3 phosphorylates CDC25C - Schizosaccharomyces pombe [Reaction:R-MMU-4088134] PLK1 phosphorylates FOXM1 - Mus musculus [Reaction:R-HSA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Homo sapiens [Reaction:R-GGA-8956659] ABL1 phosphorylates YAP1 - Gallus gallus [Reaction:R-HSA-170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex - Homo sapiens [Reaction:R-SCE-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Saccharomyces cerevisiae [Reaction:R-RNO-5686578] Activated ATM phosphorylates ABL1 - Rattus norvegicus [Reaction:R-RNO-379832] CaMKIV phosphorylates Creb1 - Rattus norvegicus [Reaction:R-CEL-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Caenorhabditis elegans [Reaction:R-SSC-176116] Recruitment and activation of Chk1 - Sus scrofa [Reaction:R-RNO-5682026] MRN bound to shortened telomeres activates ATM - Rattus norvegicus [Reaction:R-SCE-6802973] PLK3 phosphorylates CDC25C - Saccharomyces cerevisiae [Reaction:R-CFA-5683930] WICH phosphorylates H2AFX on Y142 - Canis familiaris [Reaction:R-SPO-5693536] ATM phosphorylates MDC1 - Schizosaccharomyces pombe [Reaction:R-MMU-6798372] ATM phosphorylates DYRK2 - Mus musculus [Reaction:R-CFA-6799097] ATM phosphorylates ZNF420 - Canis familiaris [Reaction:R-XTR-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Xenopus tropicalis [Reaction:R-MMU-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Mus musculus [Reaction:R-DRE-6805470] AMPK phosphorylates TP53 - Danio rerio [Reaction:R-DME-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Drosophila melanogaster [Reaction:R-HSA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Homo sapiens [Reaction:R-PFA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Plasmodium falciparum [Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens [Reaction:R-DME-6805126] AURKB phosphorylates TP53 - Drosophila melanogaster [Reaction:R-CFA-211164] AKT phosphorylates FOXO1A - Canis familiaris [Reaction:R-CEL-168136] Activated JNKs phosphorylate c-JUN - Caenorhabditis elegans [Reaction:R-MMU-176116] Recruitment and activation of Chk1 - Mus musculus [Reaction:R-SSC-5195402] CDK1 phosphorylates LPIN - Sus scrofa [Reaction:R-CEL-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Caenorhabditis elegans [Reaction:R-SSC-6805479] TP53RK phosphorylates TP53 - Sus scrofa [Reaction:R-CEL-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Caenorhabditis elegans [Reaction:R-DRE-6802973] PLK3 phosphorylates CDC25C - Danio rerio [Reaction:R-MMU-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Mus musculus [Reaction:R-MMU-8956659] ABL1 phosphorylates YAP1 - Mus musculus [Reaction:R-HSA-167097] HIV Promoter Opening: First Transition - Homo sapiens [Reaction:R-CFA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Canis familiaris [Reaction:R-DME-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Drosophila melanogaster [Reaction:R-CFA-5686578] Activated ATM phosphorylates ABL1 - Canis familiaris [Reaction:R-DRE-4088134] PLK1 phosphorylates FOXM1 - Danio rerio [Reaction:R-MMU-5693536] ATM phosphorylates MDC1 - Mus musculus [Reaction:R-SSC-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Sus scrofa [Reaction:R-CFA-349455] Phosphorylation of MDM4 by ATM - Canis familiaris [Reaction:R-SSC-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Sus scrofa [Reaction:R-RNO-3222020] NUAK1 phosphorylates TP53 - Rattus norvegicus [Reaction:R-RNO-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Rattus norvegicus [Reaction:R-CFA-69891] Phosphorylation and activation of CHEK2 by ATM - Canis familiaris [Reaction:R-CFA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Canis familiaris [Reaction:R-GGA-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Gallus gallus [Reaction:R-MMU-6805640] AKT phosphorylates KAT6A - Mus musculus [Reaction:R-SPO-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Schizosaccharomyces pombe [Reaction:R-RNO-6805276] CDK5 phosphorylates TP53 - Rattus norvegicus [Reaction:R-DME-5685230] CHEK1 phosphorylates RAD51 - Drosophila melanogaster [Reaction:R-DRE-176298] Activation of claspin - Danio rerio [Reaction:R-SSC-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Sus scrofa [Reaction:R-DME-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Drosophila melanogaster [Reaction:R-HSA-448948] Phosphorylation of E proteins by p38 MAPK - Homo sapiens [Reaction:R-CEL-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Caenorhabditis elegans [Reaction:R-DME-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Drosophila melanogaster [Reaction:R-DME-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Drosophila melanogaster [Reaction:R-SSC-349426] Phosphorylation of MDM4 by CHEK2 - Sus scrofa [Reaction:R-CFA-3371567] DBC1 is phosphorylated by ATM/ART - Canis familiaris [Reaction:R-SPO-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Schizosaccharomyces pombe [Reaction:R-DDI-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Dictyostelium discoideum [Reaction:R-MMU-3222006] STK11 (LKB1) phosphorylates NUAK1 - Mus musculus [Reaction:R-GGA-6805640] AKT phosphorylates KAT6A - Gallus gallus [Reaction:R-MMU-8868677] Cdk5:p25 phosphorylates Jun - Mus musculus [Reaction:R-RNO-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Rattus norvegicus [Reaction:R-RNO-176298] Activation of claspin - Rattus norvegicus [Reaction:R-HSA-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Homo sapiens [Reaction:R-DRE-211164] AKT phosphorylates FOXO1A - Danio rerio [Reaction:R-CEL-5082387] Phosphorylation of HSF1 at Ser230 induces transactivation - Caenorhabditis elegans [Reaction:R-SSC-8849463] PTK6 phosphorylates SFPQ - Sus scrofa [Reaction:R-RNO-5683801] CHEK2 phosphorylates BRCA1 - Rattus norvegicus [Reaction:R-MMU-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Mus musculus [Reaction:R-GGA-438019] activated chicken MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus [Reaction:R-SPO-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Schizosaccharomyces pombe [Reaction:R-CEL-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Caenorhabditis elegans [Reaction:R-SSC-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Sus scrofa [Reaction:R-MMU-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Mus musculus [Reaction:R-MMU-6799097] ATM phosphorylates ZNF420 - Mus musculus [Reaction:R-XTR-6805479] TP53RK phosphorylates TP53 - Xenopus tropicalis [Reaction:R-RNO-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Rattus norvegicus [Reaction:R-SPO-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Schizosaccharomyces pombe [Reaction:R-MMU-8848975] PTK6 phosphorylates KHDRBS1 - Mus musculus [Reaction:R-GGA-6798372] ATM phosphorylates DYRK2 - Gallus gallus [Reaction:R-SCE-448955] Phosphorylation of MEF2 proteins by p38 - Saccharomyces cerevisiae [Reaction:R-GGA-217136] Phosphorylation of Chk1 by ATM upon DNA damage - Gallus gallus [Reaction:R-GGA-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Gallus gallus [Reaction:R-XTR-5683930] WICH phosphorylates H2AFX on Y142 - Xenopus tropicalis [Reaction:R-RNO-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Rattus norvegicus [Reaction:R-MMU-8878054] HIPK2 phosphorylates RUNX1 - Mus musculus [Reaction:R-HSA-8849463] PTK6 phosphorylates SFPQ - Homo sapiens [Reaction:R-DRE-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Danio rerio [Reaction:R-XTR-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Xenopus tropicalis [Reaction:R-GGA-216941] Phosphorylation of Chk1 by ATR - Gallus gallus [Reaction:R-RNO-349455] Phosphorylation of MDM4 by ATM - Rattus norvegicus [Reaction:R-MMU-5195402] CDK1 phosphorylates LPIN - Mus musculus [Reaction:R-DME-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Drosophila melanogaster [Reaction:R-GGA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Gallus gallus [Reaction:R-XTR-168136] Activated JNKs phosphorylate c-JUN - Xenopus tropicalis [Reaction:R-GGA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Gallus gallus [Reaction:R-DME-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Drosophila melanogaster [Reaction:R-GGA-353455] Autophosphorylation of DNA-PKcs - Gallus gallus [Reaction:R-CFA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Canis familiaris [Reaction:R-CFA-5683792] p-T68-CHEK2 autophosphorylates - Canis familiaris [Reaction:R-CFA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Canis familiaris [Reaction:R-SSC-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Sus scrofa [Reaction:R-XTR-6798372] ATM phosphorylates DYRK2 - Xenopus tropicalis [Reaction:R-CFA-5693598] ATM phosphorylates NBN - Canis familiaris [Reaction:R-HSA-448955] Phosphorylation of MEF2 proteins by p38 - Homo sapiens [Reaction:R-DRE-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Danio rerio [Reaction:R-DME-8878054] HIPK2 phosphorylates RUNX1 - Drosophila melanogaster [Reaction:R-DDI-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Dictyostelium discoideum [Reaction:R-SSC-5685230] CHEK1 phosphorylates RAD51 - Sus scrofa [Reaction:R-CFA-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Canis familiaris [Reaction:R-MMU-211164] AKT phosphorylates FOXO1A - Mus musculus [Reaction:R-RNO-448955] Phosphorylation of MEF2 proteins by p38 - Rattus norvegicus [Reaction:R-CEL-5684096] CDK2 phosphorylates RBBP8 - Caenorhabditis elegans [Reaction:R-SCE-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Saccharomyces cerevisiae [Reaction:R-MMU-6805470] AMPK phosphorylates TP53 - Mus musculus [Reaction:R-GGA-448955] Phosphorylation of MEF2 proteins by p38 - Gallus gallus [Reaction:R-GGA-176298] Activation of claspin - Gallus gallus [Reaction:R-HSA-5684096] CDK2 phosphorylates RBBP8 - Homo sapiens [Reaction:R-RNO-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Rattus norvegicus [Reaction:R-DDI-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Dictyostelium discoideum [Reaction:R-SSC-8849042] PTK6 phosphorylates KHDRBS3 - Sus scrofa [Reaction:R-SCE-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Saccharomyces cerevisiae [Reaction:R-CEL-6798372] ATM phosphorylates DYRK2 - Caenorhabditis elegans [Reaction:R-CEL-3371567] DBC1 is phosphorylated by ATM/ART - Caenorhabditis elegans [Reaction:R-GGA-442913] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Gallus gallus [Reaction:R-GGA-69891] Phosphorylation and activation of CHEK2 by ATM - Gallus gallus [Reaction:R-MMU-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Mus musculus [Reaction:R-MMU-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Mus musculus [Reaction:R-DRE-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Danio rerio [Reaction:R-MMU-6802973] PLK3 phosphorylates CDC25C - Mus musculus [Reaction:R-CFA-8878054] HIPK2 phosphorylates RUNX1 - Canis familiaris [Reaction:R-DRE-5683792] p-T68-CHEK2 autophosphorylates - Danio rerio [Reaction:R-DME-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Drosophila melanogaster [Reaction:R-RNO-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Rattus norvegicus [Reaction:R-MMU-8868383] Cdk5:p25 phosphorylates lamin B1 - Mus musculus [Reaction:R-HSA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Homo sapiens [Reaction:R-DME-6805059] CK2:FACT phosphorylates TP53 - Drosophila melanogaster [Reaction:R-SPO-5682598] ATM phosphorylates HERC2 - Schizosaccharomyces pombe [Reaction:R-DRE-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Danio rerio [Reaction:R-CEL-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Caenorhabditis elegans [Reaction:R-BTA-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Bos taurus [Reaction:R-MMU-5683964] ATM phosphorylates EYA1-4 - Mus musculus [Reaction:R-HSA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Homo sapiens [Reaction:R-HSA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Homo sapiens [Reaction:R-DME-8849042] PTK6 phosphorylates KHDRBS3 - Drosophila melanogaster [Reaction:R-XTR-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Xenopus tropicalis [Reaction:R-HSA-176298] Activation of claspin - Homo sapiens [Reaction:R-SSC-4088134] PLK1 phosphorylates FOXM1 - Sus scrofa [Reaction:R-CEL-349444] Phosphorylation of COP1 at Ser-387 by ATM - Caenorhabditis elegans [Reaction:R-DRE-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Danio rerio [Reaction:R-CFA-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Canis familiaris [Reaction:R-DME-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Drosophila melanogaster [Reaction:R-HSA-5687090] p-S MAPK6 phosphorylates NCOA3 - Homo sapiens [Reaction:R-GGA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Gallus gallus [Reaction:R-CEL-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Caenorhabditis elegans [Reaction:R-RNO-8849463] PTK6 phosphorylates SFPQ - Rattus norvegicus [Reaction:R-DDI-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Dictyostelium discoideum [Reaction:R-CFA-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Canis familiaris [Reaction:R-PFA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Plasmodium falciparum [Reaction:R-BTA-3239014] MAPKAPK5 phosphorylates TP53 - Bos taurus [Reaction:R-MMU-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Mus musculus [Reaction:R-CFA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Canis familiaris [Reaction:R-CFA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Canis familiaris [Reaction:R-HSA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Homo sapiens [Reaction:R-RNO-69891] Phosphorylation and activation of CHEK2 by ATM - Rattus norvegicus [Reaction:R-RNO-3371567] DBC1 is phosphorylated by ATM/ART - Rattus norvegicus [Reaction:R-SPO-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Schizosaccharomyces pombe [Reaction:R-HSA-6805399] TAF1 phosphorylates TP53 - Homo sapiens [Reaction:R-CEL-5682598] ATM phosphorylates HERC2 - Caenorhabditis elegans [Reaction:R-RNO-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Rattus norvegicus [Reaction:R-HSA-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Homo sapiens [Reaction:R-DME-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Drosophila melanogaster [Reaction:R-SSC-5683792] p-T68-CHEK2 autophosphorylates - Sus scrofa [Reaction:R-DRE-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Danio rerio [Reaction:R-DRE-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Danio rerio [Reaction:R-DRE-8848975] PTK6 phosphorylates KHDRBS1 - Danio rerio [Reaction:R-CFA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Canis familiaris [Reaction:R-CFA-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Canis familiaris [Reaction:R-MMU-349444] Phosphorylation of COP1 at Ser-387 by ATM - Mus musculus [Reaction:R-DME-168136] Activated JNKs phosphorylate c-JUN - Drosophila melanogaster [Reaction:R-MMU-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Mus musculus [Reaction:R-GGA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Gallus gallus [Reaction:R-MMU-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Mus musculus [Reaction:R-GGA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Gallus gallus [Reaction:R-MMU-5682026] MRN bound to shortened telomeres activates ATM - Mus musculus [Reaction:R-HSA-8849042] PTK6 phosphorylates KHDRBS3 - Homo sapiens [Reaction:R-HSA-8848975] PTK6 phosphorylates KHDRBS1 - Homo sapiens [Reaction:R-DRE-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Danio rerio [Reaction:R-DME-6799097] ATM phosphorylates ZNF420 - Drosophila melanogaster [Reaction:R-DRE-349426] Phosphorylation of MDM4 by CHEK2 - Danio rerio [Reaction:R-MMU-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Mus musculus [Reaction:R-CEL-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Caenorhabditis elegans [Reaction:R-GGA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Gallus gallus [Reaction:R-XTR-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Xenopus tropicalis [Reaction:R-XTR-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Xenopus tropicalis [Reaction:R-DDI-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Dictyostelium discoideum [Reaction:R-HSA-75028] Phosphorylation of Wee1 kinase by Chk1 - Homo sapiens [Reaction:R-CFA-176298] Activation of claspin - Canis familiaris [Reaction:R-SSC-5687090] p-S MAPK6 phosphorylates NCOA3 - Sus scrofa [Reaction:R-SSC-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Sus scrofa [Reaction:R-CEL-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Caenorhabditis elegans [Reaction:R-DRE-6805126] AURKB phosphorylates TP53 - Danio rerio [Reaction:R-RNO-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Rattus norvegicus [Reaction:R-DRE-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Danio rerio [Reaction:R-XTR-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Xenopus tropicalis [Reaction:R-MMU-5693540] MRN activates ATM - Mus musculus [Reaction:R-DRE-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Danio rerio [Reaction:R-BTA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Bos taurus [Reaction:R-DME-5683792] p-T68-CHEK2 autophosphorylates - Drosophila melanogaster [Reaction:R-DRE-5693598] ATM phosphorylates NBN - Danio rerio [Reaction:R-CEL-8956659] ABL1 phosphorylates YAP1 - Caenorhabditis elegans [Reaction:R-DME-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Drosophila melanogaster [Reaction:R-DDI-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Dictyostelium discoideum [Reaction:R-RNO-6805103] AURKA phosphorylates TP53 - Rattus norvegicus [Reaction:R-BTA-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Bos taurus [Reaction:R-RNO-8956659] ABL1 phosphorylates YAP1 - Rattus norvegicus [Reaction:R-HSA-6805479] TP53RK phosphorylates TP53 - Homo sapiens [Reaction:R-RNO-5685230] CHEK1 phosphorylates RAD51 - Rattus norvegicus [Reaction:R-NUL-3245934] Mapk1 (Erk2) phosphorylates ERF - Homo sapiens [Reaction:R-DME-8848975] PTK6 phosphorylates KHDRBS1 - Drosophila melanogaster [Reaction:R-DRE-6805059] CK2:FACT phosphorylates TP53 - Danio rerio [Reaction:R-RNO-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Rattus norvegicus [Reaction:R-DRE-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Danio rerio [Reaction:R-XTR-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Xenopus tropicalis [Reaction:R-DRE-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Danio rerio [Reaction:R-CEL-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Caenorhabditis elegans [Reaction:R-HSA-8878054] HIPK2 phosphorylates RUNX1 - Homo sapiens [Reaction:R-DRE-6798372] ATM phosphorylates DYRK2 - Danio rerio [Reaction:R-DME-5195402] CDK1 phosphorylates LPIN - Drosophila melanogaster [Reaction:R-SSC-5693540] MRN activates ATM - Sus scrofa [Reaction:R-HSA-4088134] PLK1 phosphorylates FOXM1 - Homo sapiens [Reaction:R-SPO-6805640] AKT phosphorylates KAT6A - Schizosaccharomyces pombe [Reaction:R-CFA-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Canis familiaris [Reaction:R-GGA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Gallus gallus [Reaction:R-XTR-5685230] CHEK1 phosphorylates RAD51 - Xenopus tropicalis [Reaction:R-DRE-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Danio rerio [Reaction:R-DDI-6805640] AKT phosphorylates KAT6A - Dictyostelium discoideum [Reaction:R-RNO-5683930] WICH phosphorylates H2AFX on Y142 - Rattus norvegicus [Reaction:R-CFA-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Canis familiaris [Reaction:R-XTR-8848975] PTK6 phosphorylates KHDRBS1 - Xenopus tropicalis [Reaction:R-RNO-6805640] AKT phosphorylates KAT6A - Rattus norvegicus [Reaction:R-PFA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Plasmodium falciparum [Reaction:R-DRE-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Danio rerio [Reaction:R-DRE-5687090] p-S MAPK6 phosphorylates NCOA3 - Danio rerio [Reaction:R-DRE-8849042] PTK6 phosphorylates KHDRBS3 - Danio rerio [Reaction:R-BTA-5682026] MRN bound to shortened telomeres activates ATM - Bos taurus [Reaction:R-XTR-5195402] CDK1 phosphorylates LPIN - Xenopus tropicalis [Reaction:R-DME-5686578] Activated ATM phosphorylates ABL1 - Drosophila melanogaster [Reaction:R-CEL-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Caenorhabditis elegans [Reaction:R-HSA-5683964] ATM phosphorylates EYA1-4 - Homo sapiens [BlackBoxEvent:R-XTR-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Xenopus tropicalis [Reaction:R-CFA-5685230] CHEK1 phosphorylates RAD51 - Canis familiaris [Reaction:R-DME-176116] Recruitment and activation of Chk1 - Drosophila melanogaster [Reaction:R-XTR-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Xenopus tropicalis [Reaction:R-SSC-6805276] CDK5 phosphorylates TP53 - Sus scrofa [Reaction:R-SSC-5682598] ATM phosphorylates HERC2 - Sus scrofa [Reaction:R-DME-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Drosophila melanogaster [Reaction:R-DDI-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Dictyostelium discoideum [Reaction:R-DRE-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Danio rerio [Reaction:R-SCE-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Saccharomyces cerevisiae [Reaction:R-DRE-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Danio rerio [Reaction:R-MMU-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Mus musculus [Reaction:R-SSC-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Sus scrofa [Reaction:R-CFA-5683801] CHEK2 phosphorylates BRCA1 - Canis familiaris [Reaction:R-SCE-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Saccharomyces cerevisiae [Reaction:R-XTR-5693540] MRN activates ATM - Xenopus tropicalis [Reaction:R-BTA-3222020] NUAK1 phosphorylates TP53 - Bos taurus [Reaction:R-XTR-5683792] p-T68-CHEK2 autophosphorylates - Xenopus tropicalis [Reaction:R-DDI-6802973] PLK3 phosphorylates CDC25C - Dictyostelium discoideum [Reaction:R-CFA-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Canis familiaris [Reaction:R-CFA-5693536] ATM phosphorylates MDC1 - Canis familiaris [Reaction:R-MMU-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Mus musculus [Reaction:R-DME-6805470] AMPK phosphorylates TP53 - Drosophila melanogaster [Reaction:R-CEL-5195402] CDK1 phosphorylates LPIN - Caenorhabditis elegans [Reaction:R-SSC-6799097] ATM phosphorylates ZNF420 - Sus scrofa [Reaction:R-XTR-8878054] HIPK2 phosphorylates RUNX1 - Xenopus tropicalis [Reaction:R-BTA-5693536] ATM phosphorylates MDC1 - Bos taurus [Reaction:R-GGA-349426] Phosphorylation of MDM4 by CHEK2 - Gallus gallus [Reaction:R-HSA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens [Reaction:R-DRE-8849463] PTK6 phosphorylates SFPQ - Danio rerio [Reaction:R-HSA-9673789] Activated JNK phosphorylates c-JUN - Homo sapiens [Reaction:R-HSA-6805276] CDK5 phosphorylates TP53 - Homo sapiens [Reaction:R-SSC-6788810] AK6 phosphorylates (d)NMPs to (d)NDPs - Sus scrofa [Reaction:R-SSC-176298] Activation of claspin - Sus scrofa [Reaction:R-SSC-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Sus scrofa [Reaction:R-RNO-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Rattus norvegicus [Reaction:R-RNO-5682598] ATM phosphorylates HERC2 - Rattus norvegicus [Reaction:R-RNO-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Rattus norvegicus [Reaction:R-MMU-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Mus musculus [Reaction:R-GGA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Gallus gallus [Reaction:R-RNO-4088134] PLK1 phosphorylates FOXM1 - Rattus norvegicus [Reaction:R-RNO-349444] Phosphorylation of COP1 at Ser-387 by ATM - Rattus norvegicus [Reaction:R-RNO-5684096] CDK2 phosphorylates RBBP8 - Rattus norvegicus [Reaction:R-XTR-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Xenopus tropicalis [Reaction:R-DME-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Drosophila melanogaster [Reaction:R-SCE-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Saccharomyces cerevisiae [Reaction:R-MMU-5686578] Activated ATM phosphorylates ABL1 - Mus musculus [Reaction:R-SSC-349444] Phosphorylation of COP1 at Ser-387 by ATM - Sus scrofa [Reaction:R-DRE-5693540] MRN activates ATM - Danio rerio [Reaction:R-HSA-8956659] ABL1 phosphorylates YAP1 - Homo sapiens [Reaction:R-SSC-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Sus scrofa [Reaction:R-CEL-448955] Phosphorylation of MEF2 proteins by p38 - Caenorhabditis elegans [Reaction:R-CFA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Canis familiaris [Reaction:R-HSA-5683930] WICH phosphorylates H2AFX on Y142 - Homo sapiens [Reaction:R-BTA-5683964] ATM phosphorylates EYA1-4 - Bos taurus [Reaction:R-DDI-5683792] p-T68-CHEK2 autophosphorylates - Dictyostelium discoideum [Reaction:R-HSA-3222020] NUAK1 phosphorylates TP53 - Homo sapiens [Reaction:R-SCE-5685230] CHEK1 phosphorylates RAD51 - Saccharomyces cerevisiae [Reaction:R-DRE-3371567] DBC1 is phosphorylated by ATM/ART - Danio rerio [Reaction:R-HSA-6805059] CK2:FACT phosphorylates TP53 - Homo sapiens [Reaction:R-RNO-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Rattus norvegicus [Reaction:R-MMU-6805103] AURKA phosphorylates TP53 - Mus musculus [Reaction:R-HSA-6798372] ATM phosphorylates DYRK2 - Homo sapiens [Reaction:R-GGA-5683792] p-T68-CHEK2 autophosphorylates - Gallus gallus [Reaction:R-CEL-5686578] Activated ATM phosphorylates ABL1 - Caenorhabditis elegans [Reaction:R-CFA-5687090] p-S MAPK6 phosphorylates NCOA3 - Canis familiaris [Reaction:R-XTR-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Xenopus tropicalis [Reaction:R-MMU-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Mus musculus [Reaction:R-XTR-8849042] PTK6 phosphorylates KHDRBS3 - Xenopus tropicalis [Reaction:R-SSC-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Sus scrofa [Reaction:R-BTA-6798372] ATM phosphorylates DYRK2 - Bos taurus [Reaction:R-DDI-5693536] ATM phosphorylates MDC1 - Dictyostelium discoideum [Reaction:R-DME-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Drosophila melanogaster [Reaction:R-MMU-69891] Phosphorylation and activation of CHEK2 by ATM - Mus musculus [Reaction:R-DRE-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Danio rerio [Reaction:R-MMU-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Mus musculus [Reaction:R-RNO-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Rattus norvegicus [Reaction:R-RNO-170087] CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes - Rattus norvegicus [Reaction:R-RNO-8849042] PTK6 phosphorylates KHDRBS3 - Rattus norvegicus [Reaction:R-GGA-265959] Phosphorylation of Chk2 by ATM upon DNA damage - Gallus gallus [Reaction:R-CEL-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Caenorhabditis elegans [Reaction:R-RNO-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Rattus norvegicus [Reaction:R-BTA-5686578] Activated ATM phosphorylates ABL1 - Bos taurus [Reaction:R-MMU-8849463] PTK6 phosphorylates SFPQ - Mus musculus [Reaction:R-MMU-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Mus musculus [Reaction:R-MMU-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Mus musculus [Reaction:R-XTR-5687090] p-S MAPK6 phosphorylates NCOA3 - Xenopus tropicalis [Reaction:R-XTR-5693598] ATM phosphorylates NBN - Xenopus tropicalis [Reaction:R-MMU-3371567] DBC1 is phosphorylated by ATM/ART - Mus musculus [Reaction:R-XTR-6805399] TAF1 phosphorylates TP53 - Xenopus tropicalis [Reaction:R-DRE-5682026] MRN bound to shortened telomeres activates ATM - Danio rerio [Reaction:R-XTR-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Xenopus tropicalis [Reaction:R-HSA-6805103] AURKA phosphorylates TP53 - Homo sapiens [Reaction:R-DRE-5686578] Activated ATM phosphorylates ABL1 - Danio rerio [Reaction:R-CEL-8878054] HIPK2 phosphorylates RUNX1 - Caenorhabditis elegans [Reaction:R-MMU-5682598] ATM phosphorylates HERC2 - Mus musculus [Reaction:R-DRE-5685156] ATR phosphorylates RPA2 - Danio rerio [Reaction:R-DDI-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Dictyostelium discoideum [Reaction:R-RNO-3239014] MAPKAPK5 phosphorylates TP53 - Rattus norvegicus [Reaction:R-CEL-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Caenorhabditis elegans [Reaction:R-BTA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Bos taurus [Reaction:R-DME-448955] Phosphorylation of MEF2 proteins by p38 - Drosophila melanogaster [Reaction:R-SPO-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Schizosaccharomyces pombe [Reaction:R-XTR-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Xenopus tropicalis [Reaction:R-RNO-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Rattus norvegicus [Reaction:R-CEL-6799097] ATM phosphorylates ZNF420 - Caenorhabditis elegans [Reaction:R-BTA-6805479] TP53RK phosphorylates TP53 - Bos taurus [Reaction:R-RNO-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Rattus norvegicus [Reaction:R-DME-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Drosophila melanogaster [Reaction:R-RNO-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Rattus norvegicus [Reaction:R-XTR-349444] Phosphorylation of COP1 at Ser-387 by ATM - Xenopus tropicalis [Reaction:R-CFA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Canis familiaris [Reaction:R-DRE-349444] Phosphorylation of COP1 at Ser-387 by ATM - Danio rerio [Reaction:R-GGA-5685156] ATR phosphorylates RPA2 - Gallus gallus [Reaction:R-HSA-75820] Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta - Homo sapiens [Reaction:R-CFA-5693540] MRN activates ATM - Canis familiaris [Reaction:R-MMU-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Mus musculus [Reaction:R-RNO-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Rattus norvegicus [Reaction:R-DRE-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Danio rerio [Reaction:R-SSC-6798372] ATM phosphorylates DYRK2 - Sus scrofa [Reaction:R-RNO-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Rattus norvegicus [Reaction:R-DME-5693536] ATM phosphorylates MDC1 - Drosophila melanogaster [Reaction:R-DRE-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Danio rerio [Reaction:R-DRE-69891] Phosphorylation and activation of CHEK2 by ATM - Danio rerio [Reaction:R-XTR-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Xenopus tropicalis [Reaction:R-DRE-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Danio rerio [Reaction:R-HSA-170156] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes - Homo sapiens [Reaction:R-XTR-4088134] PLK1 phosphorylates FOXM1 - Xenopus tropicalis [Reaction:R-DME-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Drosophila melanogaster [Reaction:R-MMU-5683792] p-T68-CHEK2 autophosphorylates - Mus musculus [Reaction:R-DDI-5082387] Phosphorylation of HSF1 at Ser230 induces transactivation - Dictyostelium discoideum [Reaction:R-SPO-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Schizosaccharomyces pombe [Reaction:R-DRE-6805479] TP53RK phosphorylates TP53 - Danio rerio [Reaction:R-GGA-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Gallus gallus [Reaction:R-XTR-448955] Phosphorylation of MEF2 proteins by p38 - Xenopus tropicalis [Reaction:R-SCE-5682026] MRN bound to shortened telomeres activates ATM - Saccharomyces cerevisiae [Reaction:R-HSA-5693536] ATM phosphorylates MDC1 - Homo sapiens [Reaction:R-MMU-174079] Phosphorylation of Cdh1 by Cyclin A:Cdk2 - Mus musculus [Reaction:R-CFA-168136] Activated JNKs phosphorylate c-JUN - Canis familiaris [Reaction:R-CEL-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Caenorhabditis elegans [Reaction:R-DRE-5693536] ATM phosphorylates MDC1 - Danio rerio [Reaction:R-HSA-9012319] p-TEFb phosphorylates serine 2 in RNA polymerase II CTD - Homo sapiens [Reaction:R-BTA-3238999] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 - Bos taurus [Reaction:R-RNO-176116] Recruitment and activation of Chk1 - Rattus norvegicus [Reaction:R-DME-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Drosophila melanogaster [Reaction:R-SSC-5683801] CHEK2 phosphorylates BRCA1 - Sus scrofa [Reaction:R-SSC-8848975] PTK6 phosphorylates KHDRBS1 - Sus scrofa [Reaction:R-XTR-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Xenopus tropicalis [Reaction:R-HSA-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Homo sapiens [Reaction:R-XTR-6805103] AURKA phosphorylates TP53 - Xenopus tropicalis [Reaction:R-RNO-6811522] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus - Rattus norvegicus [Reaction:R-MMU-3239014] MAPKAPK5 phosphorylates TP53 - Mus musculus [Reaction:R-RNO-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Rattus norvegicus [Reaction:R-CFA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Canis familiaris [Reaction:R-CFA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Canis familiaris [Reaction:R-RNO-8848975] PTK6 phosphorylates KHDRBS1 - Rattus norvegicus [Reaction:R-SSC-6805103] AURKA phosphorylates TP53 - Sus scrofa [Reaction:R-SCE-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Saccharomyces cerevisiae [Reaction:R-SSC-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Sus scrofa [Reaction:R-GGA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Gallus gallus [Reaction:R-DRE-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Danio rerio [Reaction:R-DME-176298] Activation of claspin - Drosophila melanogaster [Reaction:R-HSA-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Homo sapiens [Reaction:R-XTR-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Xenopus tropicalis [Reaction:R-GGA-168136] Activated JNKs phosphorylate c-JUN - Gallus gallus [Reaction:R-DRE-349455] Phosphorylation of MDM4 by ATM - Danio rerio [Reaction:R-MMU-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Mus musculus [BlackBoxEvent:R-HSA-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Homo sapiens [Reaction:R-SSC-69891] Phosphorylation and activation of CHEK2 by ATM - Sus scrofa [Reaction:R-RNO-6805126] AURKB phosphorylates TP53 - Rattus norvegicus [Reaction:R-XTR-8878050] HIPK2 phosphorylates RUNX1 and EP300 - Xenopus tropicalis [Reaction:R-HSA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Homo sapiens [Reaction:R-BTA-168136] Activated JNKs phosphorylate c-JUN - Bos taurus [Reaction:R-SCE-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Saccharomyces cerevisiae [Reaction:R-XTR-5692779] p-S182 MAPKAPK5 phosphorylates FOXO1 - Xenopus tropicalis [Reaction:R-MMU-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Mus musculus [Reaction:R-SSC-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Sus scrofa [Reaction:R-SCE-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Saccharomyces cerevisiae [Reaction:R-HSA-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Homo sapiens [Reaction:R-SCE-5693540] MRN activates ATM - Saccharomyces cerevisiae [Reaction:R-SSC-6802973] PLK3 phosphorylates CDC25C - Sus scrofa [Reaction:R-XTR-8849463] PTK6 phosphorylates SFPQ - Xenopus tropicalis [Reaction:R-DRE-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Danio rerio [Reaction:R-SCE-5683792] p-T68-CHEK2 autophosphorylates - Saccharomyces cerevisiae [Reaction:R-SSC-168053] Phosphorylated MAPKs phosphorylate ATF-2 - Sus scrofa [Reaction:R-XTR-5683801] CHEK2 phosphorylates BRCA1 - Xenopus tropicalis [Reaction:R-RNO-5687090] p-S MAPK6 phosphorylates NCOA3 - Rattus norvegicus [Reaction:R-XTR-6805276] CDK5 phosphorylates TP53 - Xenopus tropicalis [Reaction:R-RNO-168136] Activated JNKs phosphorylate c-JUN - Rattus norvegicus [Reaction:R-XTR-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Xenopus tropicalis [Reaction:R-SCE-6805640] AKT phosphorylates KAT6A - Saccharomyces cerevisiae [Reaction:R-HSA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Homo sapiens [Reaction:R-HSA-5195402] CDK1 phosphorylates LPIN - Homo sapiens [Reaction:R-SPO-448955] Phosphorylation of MEF2 proteins by p38 - Schizosaccharomyces pombe [Reaction:R-DRE-8956659] ABL1 phosphorylates YAP1 - Danio rerio [Reaction:R-RNO-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Rattus norvegicus [Reaction:R-GGA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Gallus gallus [Reaction:R-SPO-5685230] CHEK1 phosphorylates RAD51 - Schizosaccharomyces pombe [Reaction:R-HSA-6805470] AMPK phosphorylates TP53 - Homo sapiens [Reaction:R-CFA-5683964] ATM phosphorylates EYA1-4 - Canis familiaris [Reaction:R-SPO-5682026] MRN bound to shortened telomeres activates ATM - Schizosaccharomyces pombe [Reaction:R-SCE-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Saccharomyces cerevisiae [Reaction:R-SSC-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Sus scrofa [Reaction:R-HSA-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Homo sapiens [Reaction:R-DME-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Drosophila melanogaster [Reaction:R-SCE-5693598] ATM phosphorylates NBN - Saccharomyces cerevisiae [Reaction:R-BTA-5693540] MRN activates ATM - Bos taurus [Reaction:R-CFA-4088134] PLK1 phosphorylates FOXM1 - Canis familiaris [Reaction:R-CFA-5682026] MRN bound to shortened telomeres activates ATM - Canis familiaris [Reaction:R-SSC-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Sus scrofa [Reaction:R-DRE-6805103] AURKA phosphorylates TP53 - Danio rerio [Reaction:R-BTA-5682598] ATM phosphorylates HERC2 - Bos taurus [Reaction:R-CEL-5693536] ATM phosphorylates MDC1 - Caenorhabditis elegans [Reaction:R-XTR-69891] Phosphorylation and activation of CHEK2 by ATM - Xenopus tropicalis [Reaction:R-DDI-448955] Phosphorylation of MEF2 proteins by p38 - Dictyostelium discoideum [Reaction:R-PFA-5195402] CDK1 phosphorylates LPIN - Plasmodium falciparum [Reaction:R-RNO-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Rattus norvegicus [Reaction:R-HSA-6802973] PLK3 phosphorylates CDC25C - Homo sapiens [Reaction:R-CEL-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Caenorhabditis elegans [Reaction:R-SSC-448955] Phosphorylation of MEF2 proteins by p38 - Sus scrofa [Reaction:R-RNO-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Rattus norvegicus [Reaction:R-RNO-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Rattus norvegicus [Reaction:R-HSA-8868340] CDK5:p25 phosphorylates lamin B1 - Homo sapiens [Reaction:R-MMU-5687090] p-S MAPK6 phosphorylates NCOA3 - Mus musculus [Reaction:R-DRE-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Danio rerio [Reaction:R-HSA-3239014] MAPKAPK5 phosphorylates TP53 - Homo sapiens [Reaction:R-CFA-5195402] CDK1 phosphorylates LPIN - Canis familiaris [Reaction:R-CEL-5685230] CHEK1 phosphorylates RAD51 - Caenorhabditis elegans [Reaction:R-CEL-8849463] PTK6 phosphorylates SFPQ - Caenorhabditis elegans [Reaction:R-MMU-448955] Phosphorylation of MEF2 proteins by p38 - Mus musculus [Reaction:R-DRE-5684096] CDK2 phosphorylates RBBP8 - Danio rerio [Reaction:R-GGA-349455] Phosphorylation of MDM4 by ATM - Gallus gallus [Reaction:R-DRE-9684118] ERCC3-facilitated RNA Pol II backtracking in TC-NER - Danio rerio [Reaction:R-DRE-5654989] SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA - Danio rerio [Reaction:R-DME-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Drosophila melanogaster [Reaction:R-DRE-176116] Recruitment and activation of Chk1 - Danio rerio [Reaction:R-RNO-6802973] PLK3 phosphorylates CDC25C - Rattus norvegicus [Reaction:R-HSA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Homo sapiens [Reaction:R-CFA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Canis familiaris [Reaction:R-MMU-176298] Activation of claspin - Mus musculus [Reaction:R-SSC-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Sus scrofa [Reaction:R-HSA-349426] Phosphorylation of MDM4 by CHEK2 - Homo sapiens [Reaction:R-DDI-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Dictyostelium discoideum [Reaction:R-HSA-211164] AKT phosphorylates FOXO1A - Homo sapiens [Reaction:R-XTR-5683964] ATM phosphorylates EYA1-4 - Xenopus tropicalis [Reaction:R-RNO-5683964] ATM phosphorylates EYA1-4 - Rattus norvegicus [Reaction:R-SSC-8956659] ABL1 phosphorylates YAP1 - Sus scrofa [Reaction:R-MMU-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Mus musculus [Reaction:R-GGA-8878054] HIPK2 phosphorylates RUNX1 - Gallus gallus [Reaction:R-HSA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Homo sapiens [Reaction:R-BTA-5683792] p-T68-CHEK2 autophosphorylates - Bos taurus [Reaction:R-DME-5082387] Phosphorylation of HSF1 at Ser230 induces transactivation - Drosophila melanogaster [Reaction:R-DDI-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Dictyostelium discoideum [Reaction:R-MMU-6788392] ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA - Mus musculus [Reaction:R-MMU-5693598] ATM phosphorylates NBN - Mus musculus [Reaction:R-CFA-174174] Phosphorylation of the Emi1 DSGxxS degron by Plk1 - Canis familiaris [Reaction:R-MMU-349426] Phosphorylation of MDM4 by CHEK2 - Mus musculus [Reaction:R-GGA-1855230] 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus - Gallus gallus [Reaction:R-DRE-8878054] HIPK2 phosphorylates RUNX1 - Danio rerio [BlackBoxEvent:R-CFA-9032751] Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 - Canis familiaris [Reaction:R-GGA-5687090] p-S MAPK6 phosphorylates NCOA3 - Gallus gallus [Reaction:R-SSC-75809] Phosphorylation of Cdc25C at Ser216 by CHEK2 - Sus scrofa [Reaction:R-BTA-5693598] ATM phosphorylates NBN - Bos taurus [Reaction:R-XTR-69604] Phosphorylation of Cdc25A at Ser-123 by Chk1 - Xenopus tropicalis [Reaction:R-BTA-450222] Active p38 MAPK phosphorylates MAPKAPK2 or 3 - Bos taurus [Reaction:R-HSA-3209160] Activated ERKs phosphorylate ERF - Homo sapiens [Reaction:R-DDI-3239019] Active p38 MAPK phosphorylates MAPKAPK5 - Dictyostelium discoideum [Reaction:R-HSA-4608825] DVL2 is phosphorylated after WNT5A binding to FZD - Homo sapiens [Reaction:R-MMU-5684096] CDK2 phosphorylates RBBP8 - Mus musculus [Reaction:R-HSA-6805126] AURKB phosphorylates TP53 - Homo sapiens [Reaction:R-MMU-6805059] CK2:FACT phosphorylates TP53 - Mus musculus [Reaction:R-RNO-6805399] TAF1 phosphorylates TP53 - Rattus norvegicus [Reaction:R-HSA-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Homo sapiens [Reaction:R-SSC-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Sus scrofa [Reaction:R-SSC-3239014] MAPKAPK5 phosphorylates TP53 - Sus scrofa [Reaction:R-GGA-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Gallus gallus [Reaction:R-DRE-6805399] TAF1 phosphorylates TP53 - Danio rerio [Reaction:R-SPO-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Schizosaccharomyces pombe [Reaction:R-XTR-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Xenopus tropicalis [Reaction:R-SSC-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Sus scrofa [Reaction:R-DME-5684096] CDK2 phosphorylates RBBP8 - Drosophila melanogaster [Reaction:R-CFA-6782131] ERCC2-facilitated RNA Pol II backtracking in TC-NER - Canis familiaris [Reaction:R-CFA-75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 - Canis familiaris [Reaction:R-SSC-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Sus scrofa [Reaction:R-CFA-176116] Recruitment and activation of Chk1 - Canis familiaris [Reaction:R-BTA-6805470] AMPK phosphorylates TP53 - Bos taurus [Reaction:R-DRE-8942836] CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 - Danio rerio [Reaction:R-MMU-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Mus musculus [Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens [Reaction:R-HSA-5682598] ATM phosphorylates HERC2 - Homo sapiens [Reaction:R-SSC-174122] Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2 - Sus scrofa [Reaction:R-HSA-450333] Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 - Homo sapiens [Reaction:R-HSA-3215391] PRMT5 is tyrosine phosphorylated by JAK2 V617F - Homo sapiens [Reaction:R-SSC-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Sus scrofa [Reaction:R-HSA-3857328] RPS6KA1/2/3 phosphorylates CEBPB on S321 - Homo sapiens [Reaction:R-HSA-176116] Recruitment and activation of Chk1 - Homo sapiens [Reaction:R-SSC-6797606] CDK12 phosphorylates RNA Pol II CTD at DNA repair genes - Sus scrofa [Reaction:R-MMU-5690996] ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA - Mus musculus [Reaction:R-CEL-174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 - Caenorhabditis elegans [Reaction:R-XTR-3239014] MAPKAPK5 phosphorylates TP53 - Xenopus tropicalis [Reaction:R-HSA-349455] Phosphorylation of MDM4 by ATM - Homo sapiens [Reaction:R-DRE-5195402] CDK1 phosphorylates LPIN - Danio rerio [Reaction:R-SSC-6805399] TAF1 phosphorylates TP53 - Sus scrofa [Reaction:R-MMU-6805399] TAF1 phosphorylates TP53 - Mus musculus [Reaction:R-DME-5682598] ATM phosphorylates HERC2 - Drosophila melanogaster
referenceEntity	[ReferenceMolecule:8869367] ADP(3-) [ChEBI:456216]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-113582

Referrals

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