Reactome | TP53 binds the BIRC5 gene

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TP53 binds the BIRC5 gene Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6797759] Orlic-Milacic, Marija, 2015-09-16
dbId	6797766
displayName	TP53 binds the BIRC5 gene
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6797763] TP53 inhibits BIRC5 expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6797760] BIRC5 Gene [nucleoplasm] [Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6797755] Transcriptional repression of the anti-apoptotic survivin gene by wild type p53
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 binds the BIRC5 gene
output	[Complex:R-HSA-6797767] p-S15,S20-TP53 Tetramer:BIRC5 Gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6797766
summation	[Summation:6797762] TP53 (p53) binds the p53 response element in the promoter of...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-6797763] TP53 inhibits BIRC5 expression
(hasEvent)	[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

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