Reactome | ATM phosphorylates TP53 at S15

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ATM phosphorylates TP53 at S15 Show undefined attributes

authored	[InstanceEdit:69508] Khanna, K, 2003-06-05 08:03:38
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693609
deleted	[Deleted:6792789] Deletion of instance: 69511
displayName	ATM phosphorylates TP53 at S15
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens [Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
figure	[Figure:69460] /figures/ATM_p53.jpg
followingEvent	[Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-3786258] TP53 binds the CDKN1A promoter - Homo sapiens [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69512] Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.\nActivation of the ATM kinase by ionizing radiation and phosphorylation of p53.\n [LiteratureReference:69520] Enhanced phosphorylation of p53 by ATM in response to DNA damage. [LiteratureReference:69530] ATM associates with and phosphorylates p53: mapping the region of interaction.
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	ATM phosphorylates TP53 at S15
orthologousEvent	[Reaction:R-DME-5693609] ATM phosphorylates TP53 at S15 - Drosophila melanogaster [Reaction:R-DRE-5693609] ATM phosphorylates TP53 at S15 - Danio rerio [Reaction:R-SSC-5693609] ATM phosphorylates TP53 at S15 - Sus scrofa [Reaction:R-BTA-5693609] ATM phosphorylates TP53 at S15 - Bos taurus [Reaction:R-CFA-5693609] ATM phosphorylates TP53 at S15 - Canis familiaris [Reaction:R-RNO-5693609] ATM phosphorylates TP53 at S15 - Rattus norvegicus [Reaction:R-MMU-5693609] ATM phosphorylates TP53 at S15 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-349474] p-S15-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens [Reaction:R-HSA-5682026] MRN bound to shortened telomeres activates ATM - Homo sapiens [Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:349472] Sanchez, Y, 2008-05-07 22:09:03 [InstanceEdit:5693179] Borowiec, James A, 2015-06-12 [InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693609
summation	[Summation:69540] In response to DNA double strand breaks, serine at position ...

Referrals

(replacementInstances)	[Deleted:6792789] Deletion of instance: 69511
(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Pathway:R-HSA-69541] Stabilization of p53
(precedingEvent)	[Reaction:R-HSA-3786258] TP53 binds the CDKN1A promoter [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53

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