Reactome | DYRK2 phosphorylates TP53

Schema > Reaction > Entries

DYRK2 phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6798365] protein serine/threonine kinase activity of p-T106,S442-DYRK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6798384] Orlic-Milacic, Marija, 2015-09-18
dbId	6798374
displayName	DYRK2 phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6798366] DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	DYRK2 phosphorylates TP53
orthologousEvent	[Reaction:R-XTR-6798374] DYRK2 phosphorylates TP53 - Xenopus tropicalis [Reaction:R-DME-6798374] DYRK2 phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DRE-6798374] DYRK2 phosphorylates TP53 - Danio rerio [Reaction:R-SSC-6798374] DYRK2 phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-6798374] DYRK2 phosphorylates TP53 - Bos taurus [Reaction:R-CFA-6798374] DYRK2 phosphorylates TP53 - Canis familiaris [Reaction:R-RNO-6798374] DYRK2 phosphorylates TP53 - Rattus norvegicus [Reaction:R-MMU-6798374] DYRK2 phosphorylates TP53 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-6798371] p-S15,S20,S46-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6798372] ATM phosphorylates DYRK2 - Homo sapiens [Reaction:R-HSA-69685] CHEK2 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6799246] CHEK1 phosphorylates TP53 - Homo sapiens [Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6798374
summation	[Summation:6798377] DYRK2 phosphorylates TP53 at serine residue S46 (Taira et al...

Referrals

(precedingEvent)	[Reaction:R-HSA-6798615] TP53 binds the TP53AIP1 gene
(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation