Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Schema > Pathway > Entries

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Show undefined attributes

authored	[InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
crossReference	[DatabaseIdentifier:12819591] BioModels Database:BIOMD0000000188 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819593] BioModels Database:BIOMD0000000634
dbId	5693565
deleted	[Deleted:6793401] Deletion of instance: 75154 [Deleted:6793258] Deletion of instance: 75148 [Deleted:6793353] Deletion of instance: 83542
displayName	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
doi	10.3180/R-HSA-5693565.3
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693606] DNA Double Strand Break Response - Homo sapiens
figure	[Figure:111406] /figures/RepairFoci.jpg
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5693598] ATM phosphorylates NBN - Homo sapiens [Reaction:R-HSA-5683930] WICH phosphorylates H2AFX on Y142 - Homo sapiens [Reaction:R-HSA-5693602] ATM recognizes H2AFX-Nucleosomes - Homo sapiens [Reaction:R-HSA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Homo sapiens [Reaction:R-HSA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Homo sapiens [Reaction:R-HSA-5683964] ATM phosphorylates EYA1-4 - Homo sapiens [Reaction:R-HSA-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX - Homo sapiens [Reaction:R-HSA-5693583] MDC1 associates with gamma-H2AFX at nuclear foci - Homo sapiens [Reaction:R-HSA-5693536] ATM phosphorylates MDC1 - Homo sapiens [Reaction:R-HSA-5682967] WHSC1 binds DNA DSBs - Homo sapiens [Reaction:R-HSA-5682983] ATM phosphorylates WHSC1 - Homo sapiens [Reaction:R-HSA-5682965] WHSC1 dimethylates histone H4 on lysine K21 at DSBs - Homo sapiens [Reaction:R-HSA-5682992] KDM4A,B bind H4K20Me2 - Homo sapiens [Reaction:R-HSA-5682588] RNF8 binds phosphorylated MDC1 at DNA DSBs - Homo sapiens [Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Homo sapiens [Reaction:R-HSA-5682598] ATM phosphorylates HERC2 - Homo sapiens [Reaction:R-HSA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Homo sapiens [Reaction:R-HSA-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 - Homo sapiens [Reaction:R-HSA-5682863] RNF168 binds DNA DSBs - Homo sapiens [Reaction:R-HSA-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Homo sapiens [Reaction:R-HSA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Homo sapiens [Reaction:R-HSA-5693566] TP53BP1 associates with H4K20Me2 at DNA DSBs - Homo sapiens [Reaction:R-HSA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Homo sapiens [Reaction:R-HSA-5683405] PPP5C dephosphorylates TP53BP1 - Homo sapiens [Reaction:R-HSA-5683384] UIMC1 and FAM175A bind DNA DSBs - Homo sapiens [Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1 - Homo sapiens [Reaction:R-HSA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Homo sapiens [Reaction:R-HSA-9701003] BAP1 binds BRCA1:BARD1 heterodimer - Homo sapiens [Reaction:R-HSA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer - Homo sapiens [Reaction:R-HSA-9707051] UBXN1 binds BRCA1:BARD1 heterodimer - Homo sapiens [Reaction:R-HSA-5683385] Formation of BRCA1-A complex at DNA DSBs - Homo sapiens [Reaction:R-HSA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Homo sapiens [Reaction:R-HSA-5683735] CHEK2 is recruited to DNA DSBs - Homo sapiens [Reaction:R-HSA-69891] Phosphorylation and activation of CHEK2 by ATM - Homo sapiens [Reaction:R-HSA-5683774] p-T68-CHEK2 dimerizes - Homo sapiens [Reaction:R-HSA-5683792] p-T68-CHEK2 autophosphorylates - Homo sapiens [Reaction:R-HSA-5683801] CHEK2 phosphorylates BRCA1 - Homo sapiens [Reaction:R-HSA-5693609] ATM phosphorylates TP53 at S15 - Homo sapiens [Reaction:R-HSA-5686578] Activated ATM phosphorylates ABL1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:5687895] Activation of the cellular DNA damage response in the absence of DNA lesions [LiteratureReference:5682158] ATM-dependent phosphorylation of nibrin in response to radiation exposure [LiteratureReference:83590] DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. [LiteratureReference:914123] ATM phosphorylates histone H2AX in response to DNA double-strand breaks [LiteratureReference:5682479] Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention [LiteratureReference:5682186] MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks [LiteratureReference:5682526] Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain [LiteratureReference:5683931] WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity [LiteratureReference:5683957] Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions [LiteratureReference:5682555] Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase [LiteratureReference:5682587] HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes [LiteratureReference:5682622] Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation [LiteratureReference:5682944] RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins [LiteratureReference:5682930] The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage [LiteratureReference:5682943] RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly [LiteratureReference:5682918] RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins [LiteratureReference:5682988] RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites [LiteratureReference:5683382] Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response [LiteratureReference:5683603] Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage [LiteratureReference:5682980] MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites [LiteratureReference:83579] Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks [LiteratureReference:5683725] Role for ATM in DNA damage-induced phosphorylation of BRCA1 [LiteratureReference:5659849] DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex [LiteratureReference:5683396] Characterisation of the sites of DNA damage-induced 53BP1 phosphorylation catalysed by ATM and ATR [LiteratureReference:110405] 53BP1, a mediator of the DNA damage checkpoint. [LiteratureReference:5683732] NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway [LiteratureReference:5683739] Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 [LiteratureReference:5686687] A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
orthologousEvent	[Pathway:R-DDI-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Dictyostelium discoideum [Pathway:R-PFA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Plasmodium falciparum [Pathway:R-SCE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Saccharomyces cerevisiae [Pathway:R-SPO-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Schizosaccharomyces pombe [Pathway:R-CEL-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Caenorhabditis elegans [Pathway:R-DME-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Drosophila melanogaster [Pathway:R-GGA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Gallus gallus [Pathway:R-XTR-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Xenopus tropicalis [Pathway:R-DRE-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Danio rerio [Pathway:R-SSC-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Sus scrofa [Pathway:R-BTA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Bos taurus [Pathway:R-CFA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Canis familiaris [Pathway:R-RNO-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Rattus norvegicus [Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Mus musculus
precedingEvent	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens [Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5693565
summation	[Summation:5693619] Activated ATM phosphorylates a number of proteins involved i...
updateTrackers	[UpdateTracker:9776530] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v75:[addHasEvent, updateContainedRLE] [UpdateTracker:9846749] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v84:[updateContainedRLE] [UpdateTracker:9775800] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v78:[updateContainedRLE] [UpdateTracker:9783043] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v57:[add_removeHasEvent, updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-5693606] DNA Double Strand Break Response
(replacementInstances)	[Deleted:6793401] Deletion of instance: 75154 [Deleted:6793258] Deletion of instance: 75148 [Deleted:6793353] Deletion of instance: 83542
(updatedInstance)	[UpdateTracker:9776530] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v75:[addHasEvent, updateContainedRLE] [UpdateTracker:9846749] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v84:[updateContainedRLE] [UpdateTracker:9775800] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v78:[updateContainedRLE] [UpdateTracker:9783043] Update Tracker - [Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - v57:[add_removeHasEvent, updateContainedRLE]

Cite Us!