Reactome | APBB1 and MAPK8 bind diphosphorylated H2AFX

Schema > Reaction > Entries

APBB1 and MAPK8 bind diphosphorylated H2AFX Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5683990] Orlic-Milacic, Marija, 2015-03-17
dbId	5683986
displayName	APBB1 and MAPK8 bind diphosphorylated H2AFX
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5683987] APBB1 [nucleoplasm] [Complex:R-HSA-5683952] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-216349] p-T,Y-MAPK8 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5683957] Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	APBB1 and MAPK8 bind diphosphorylated H2AFX
orthologousEvent	[Reaction:R-GGA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Gallus gallus [Reaction:R-DRE-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Danio rerio [Reaction:R-SSC-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Sus scrofa [Reaction:R-BTA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Bos taurus [Reaction:R-CFA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Canis familiaris [Reaction:R-RNO-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Rattus norvegicus [Reaction:R-MMU-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Mus musculus
output	[Complex:R-HSA-5683988] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5683986
summation	[Summation:5683989] In the absence of sufficient EYA1-4 activity, APBB1 (FE65) b...

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[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks