Reactome | RNF168 binds DNA DSBs

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RNF168 binds DNA DSBs Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682862] Orlic-Milacic, Marija, 2015-03-11
dbId	5682863
displayName	RNF168 binds DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Homo sapiens
input	[Complex:R-HSA-5682623] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-4551605] RNF168 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682587] HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes [LiteratureReference:5682918] RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins [LiteratureReference:5682930] The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage [LiteratureReference:5682916] RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling [LiteratureReference:5682622] Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RNF168 binds DNA DSBs
orthologousEvent	[Reaction:R-MMU-5682863] RNF168 binds DNA DSBs - Mus musculus [Reaction:R-GGA-5682863] RNF168 binds DNA DSBs - Gallus gallus [Reaction:R-DRE-5682863] RNF168 binds DNA DSBs - Danio rerio [Reaction:R-SSC-5682863] RNF168 binds DNA DSBs - Sus scrofa [Reaction:R-BTA-5682863] RNF168 binds DNA DSBs - Bos taurus [Reaction:R-CFA-5682863] RNF168 binds DNA DSBs - Canis familiaris [Reaction:R-RNO-5682863] RNF168 binds DNA DSBs - Rattus norvegicus
output	[Complex:R-HSA-5682859] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682863
summation	[Summation:5682914] The recruitment of RNF168, an E3 ubiquitin ligase, to DNA do...
updateTrackers	[UpdateTracker:9775731] Update Tracker - [Reaction:5682863] RNF168 binds DNA DSBs - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775731] Update Tracker - [Reaction:5682863] RNF168 binds DNA DSBs - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-HSA-5682858] RNF8 and RNF168 ubiquitinate H2AFX

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