Reactome | Phosphorylation of BRCA1-A complex at multiple sites by ATM

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Phosphorylation of BRCA1-A complex at multiple sites by ATM Show undefined attributes

authored	[InstanceEdit:83535] Matthews, L, 2003-11-18 00:00:00
catalystActivity	[CatalystActivity:5683607] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693551
deleted	[Deleted:6793506] Deletion of instance: 75239
displayName	Phosphorylation of BRCA1-A complex at multiple sites by ATM
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-5683735] CHEK2 is recruited to DNA DSBs - Homo sapiens
input	6 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5683387] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:83579] Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks [LiteratureReference:5683725] Role for ATM in DNA damage-induced phosphorylation of BRCA1 [LiteratureReference:5683721] Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress [LiteratureReference:5659849] DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Phosphorylation of BRCA1-A complex at multiple sites by ATM
orthologousEvent	[Reaction:R-GGA-265987] Phosphorylation of BRCA1 - Gallus gallus [Reaction:R-MMU-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Mus musculus [Reaction:R-GGA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Gallus gallus [Reaction:R-DRE-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Danio rerio [Reaction:R-SSC-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Sus scrofa [Reaction:R-BTA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Bos taurus [Reaction:R-CFA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Canis familiaris [Reaction:R-RNO-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Rattus norvegicus
output	6 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5683605] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5683385] Formation of BRCA1-A complex at DNA DSBs - Homo sapiens
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
revised	[InstanceEdit:5659844] Orlic-Milacic, Marija, 2014-12-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5693551
summation	[Summation:83580] ATM phosphorylates BRCA1 at serine residues S1387, S1423, S1...
updateTrackers	[UpdateTracker:9846790] Update Tracker - [Reaction:5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - v84:[modifyText]

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(updatedInstance)	[UpdateTracker:9846790] Update Tracker - [Reaction:5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - v84:[modifyText]
(replacementInstances)	[Deleted:6793506] Deletion of instance: 75239
(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-HSA-5683735] CHEK2 is recruited to DNA DSBs

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