Reactome | ATM phosphorylates HERC2

Schema > Reaction > Entries

ATM phosphorylates HERC2 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5682602] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682604] Orlic-Milacic, Marija, 2015-03-09
dbId	5682598
displayName	ATM phosphorylates HERC2
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682587] HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	ATM phosphorylates HERC2
orthologousEvent	[Reaction:R-MMU-5682598] ATM phosphorylates HERC2 - Mus musculus [Reaction:R-GGA-5682598] ATM phosphorylates HERC2 - Gallus gallus [Reaction:R-DRE-5682598] ATM phosphorylates HERC2 - Danio rerio [Reaction:R-SSC-5682598] ATM phosphorylates HERC2 - Sus scrofa [Reaction:R-BTA-5682598] ATM phosphorylates HERC2 - Bos taurus [Reaction:R-CFA-5682598] ATM phosphorylates HERC2 - Canis familiaris [Reaction:R-RNO-5682598] ATM phosphorylates HERC2 - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5682599] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682598
summation	[Summation:5682603] ATM phosphorylates HERC2 on threonine residue T4827. This th...

Referrals

(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-HSA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs