Reactome | Activated ATM phosphorylates ABL1

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Activated ATM phosphorylates ABL1 Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5686581] Orlic-Milacic, Marija, 2015-04-02
dbId	5686578
displayName	Activated ATM phosphorylates ABL1
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-8956659] ABL1 phosphorylates YAP1 - Homo sapiens [Reaction:R-HSA-5686587] ABL1 phosphorylates RAD52 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5686579] ABL1 [nucleoplasm] [SimpleEntity:R-ALL-29358] ATP [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:217096] Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	Activated ATM phosphorylates ABL1
orthologousEvent	[Reaction:R-DME-5686578] Activated ATM phosphorylates ABL1 - Drosophila melanogaster [Reaction:R-GGA-5686578] Activated ATM phosphorylates ABL1 - Gallus gallus [Reaction:R-SSC-5686578] Activated ATM phosphorylates ABL1 - Sus scrofa [Reaction:R-BTA-5686578] Activated ATM phosphorylates ABL1 - Bos taurus [Reaction:R-CFA-5686578] Activated ATM phosphorylates ABL1 - Canis familiaris [Reaction:R-RNO-5686578] Activated ATM phosphorylates ABL1 - Rattus norvegicus [Reaction:R-MMU-5686578] Activated ATM phosphorylates ABL1 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5686576] p-S456-ABL1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693540] MRN activates ATM - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5686578
summation	[Summation:5686577] ATM, activated in response to DNA damage in the form of doub...

Referrals

(precedingEvent)	[Reaction:R-HSA-8956659] ABL1 phosphorylates YAP1 [Reaction:R-HSA-5686587] ABL1 phosphorylates RAD52
(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks