Reactome | BRCA1:BARD1 heterodimer autoubiquitinates

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BRCA1:BARD1 heterodimer autoubiquitinates Show undefined attributes

authored	[InstanceEdit:9702562] Orlic-Milacic, Marija, 2020-09-30
catalystActivity	[CatalystActivity:9701027] ubiquitin-protein transferase activity of BRCA1:BARD1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701005] Orlic-Milacic, Marija, 2020-09-23
dbId	9701000
displayName	BRCA1:BARD1 heterodimer autoubiquitinates
edited	[InstanceEdit:9706872] Orlic-Milacic, Marija, 2020-11-09
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-9707051] UBXN1 binds BRCA1:BARD1 heterodimer - Homo sapiens [Reaction:R-HSA-5683385] Formation of BRCA1-A complex at DNA DSBs - Homo sapiens
input	[Complex:R-HSA-5659802] BRCA1:BARD1 [nucleoplasm] 6 × [DefinedSet:R-HSA-6782648] K6-Ub [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9701008] Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase [LiteratureReference:9700997] The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin [LiteratureReference:9701001] Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	BRCA1:BARD1 heterodimer autoubiquitinates
orthologousEvent	[Reaction:R-MMU-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Mus musculus [Reaction:R-DDI-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Dictyostelium discoideum [Reaction:R-GGA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Gallus gallus [Reaction:R-SSC-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Sus scrofa [Reaction:R-BTA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Bos taurus [Reaction:R-CFA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Canis familiaris [Reaction:R-RNO-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Rattus norvegicus
output	[Complex:R-HSA-9701028] K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1 - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-8868791] Negative regulation by 'BAP1:BARD1 [nucleoplasm]'
releaseDate	2020-12-08
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9706944] Baer, Richard J, 2020-11-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9701000
summation	[Summation:9701020] In vivo, most BRCA1 and BARD1 polypeptides exist in the form...

Referrals

(precedingEvent)	[Reaction:R-HSA-9707051] UBXN1 binds BRCA1:BARD1 heterodimer [Reaction:R-HSA-5683385] Formation of BRCA1-A complex at DNA DSBs
(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks