Reactome | WHSC1 binds DNA DSBs

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WHSC1 binds DNA DSBs Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5682966] Orlic-Milacic, Marija, 2015-03-11
dbId	5682967
displayName	WHSC1 binds DNA DSBs
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-5682983] ATM phosphorylates WHSC1 - Homo sapiens
input	[Complex:R-HSA-5682530] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-1183215] WHSC1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5682980] MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	WHSC1 binds DNA DSBs
orthologousEvent	[Reaction:R-MMU-5682967] WHSC1 binds DNA DSBs - Mus musculus [Reaction:R-GGA-5682967] WHSC1 binds DNA DSBs - Gallus gallus [Reaction:R-DRE-5682967] WHSC1 binds DNA DSBs - Danio rerio [Reaction:R-SSC-5682967] WHSC1 binds DNA DSBs - Sus scrofa [Reaction:R-BTA-5682967] WHSC1 binds DNA DSBs - Bos taurus [Reaction:R-CFA-5682967] WHSC1 binds DNA DSBs - Canis familiaris [Reaction:R-RNO-5682967] WHSC1 binds DNA DSBs - Rattus norvegicus
output	[Complex:R-HSA-5682968] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5693536] ATM phosphorylates MDC1 - Homo sapiens
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5682967
summation	[Summation:5682985] The histone methyltransferase WHSC1 (MMSET) is recruited to ...
updateTrackers	[UpdateTracker:9775966] Update Tracker - [Reaction:5682967] WHSC1 binds DNA DSBs - v78:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775966] Update Tracker - [Reaction:5682967] WHSC1 binds DNA DSBs - v78:[modifyText]
(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-HSA-5682983] ATM phosphorylates WHSC1