Reactome | Phosphorylation and activation of CHEK2 by ATM

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Phosphorylation and activation of CHEK2 by ATM Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
catalystActivity	[CatalystActivity:5683600] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
dbId	69891
displayName	Phosphorylation and activation of CHEK2 by ATM
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-69473] G2/M DNA damage checkpoint - Homo sapiens [Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
followingEvent	[Reaction:R-HSA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 - Homo sapiens [Reaction:R-HSA-5683774] p-T68-CHEK2 dimerizes - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-5683737] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:83554] A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. [LiteratureReference:179441] Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro [LiteratureReference:5683739] Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1 [LiteratureReference:5683742] DNA damage regulates Chk2 association with chromatin [LiteratureReference:110405] 53BP1, a mediator of the DNA damage checkpoint.
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Phosphorylation and activation of CHEK2 by ATM
orthologousEvent	[Reaction:R-MMU-69891] Phosphorylation and activation of CHEK2 by ATM - Mus musculus [Reaction:R-GGA-69891] Phosphorylation and activation of CHEK2 by ATM - Gallus gallus [Reaction:R-SSC-69891] Phosphorylation and activation of CHEK2 by ATM - Sus scrofa [Reaction:R-BTA-69891] Phosphorylation and activation of CHEK2 by ATM - Bos taurus [Reaction:R-CFA-69891] Phosphorylation and activation of CHEK2 by ATM - Canis familiaris [Reaction:R-RNO-69891] Phosphorylation and activation of CHEK2 by ATM - Rattus norvegicus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-5683605] DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-113825] p-T68-CHEK2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5683735] CHEK2 is recruited to DNA DSBs - Homo sapiens
releaseDate	2003-11-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69891
summation	[Summation:179045] Activated ATM phosphorylates CHEK2 (CHK2, Cds1) on threonine...

Referrals

(hasEvent)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Pathway:R-HSA-69473] G2/M DNA damage checkpoint
(precedingEvent)	[Reaction:R-HSA-69608] Phosphorylation of Cdc25A at Ser-123 by Chk2 [Reaction:R-HSA-5683774] p-T68-CHEK2 dimerizes [NegativePrecedingEvent:9766480] Futile Cycle: Phosphorylation and activation of CHEK2 by ATM

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