Reactome | DNA Double Strand Break Response

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DNA Double Strand Break Response Show undefined attributes

authored	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
created	[InstanceEdit:5693618] Orlic-Milacic, Marija, 2015-05-16
dbId	5693606
deleted	[Deleted:6793413] Deletion of instance: 5685940
diseasePathways	[Pathway:R-HSA-9699150] Defective DNA double strand break response due to BARD1 loss of function - Homo sapiens [Pathway:R-HSA-9663199] Defective DNA double strand break response due to BRCA1 loss of function - Homo sapiens
displayName	DNA Double Strand Break Response
edited	[InstanceEdit:5692524] Orlic-Milacic, Marija, 2015-05-12
eventOf	[Pathway:R-HSA-5693532] DNA Double-Strand Break Repair - Homo sapiens
followingEvent	[Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) - Homo sapiens [Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:9349] double-strand break repair
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-5693548] Sensing of DNA Double Strand Breaks - Homo sapiens [Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:5686229] The DNA damage response: making it safe to play with knives
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DNA Double Strand Break Response
orthologousEvent	[Pathway:R-DDI-5693606] DNA Double Strand Break Response - Dictyostelium discoideum [Pathway:R-MMU-5693606] DNA Double Strand Break Response - Mus musculus [Pathway:R-PFA-5693606] DNA Double Strand Break Response - Plasmodium falciparum [Pathway:R-SCE-5693606] DNA Double Strand Break Response - Saccharomyces cerevisiae [Pathway:R-SPO-5693606] DNA Double Strand Break Response - Schizosaccharomyces pombe [Pathway:R-CEL-5693606] DNA Double Strand Break Response - Caenorhabditis elegans [Pathway:R-DME-5693606] DNA Double Strand Break Response - Drosophila melanogaster [Pathway:R-GGA-5693606] DNA Double Strand Break Response - Gallus gallus [Pathway:R-XTR-5693606] DNA Double Strand Break Response - Xenopus tropicalis [Pathway:R-DRE-5693606] DNA Double Strand Break Response - Danio rerio [Pathway:R-SSC-5693606] DNA Double Strand Break Response - Sus scrofa [Pathway:R-BTA-5693606] DNA Double Strand Break Response - Bos taurus [Pathway:R-CFA-5693606] DNA Double Strand Break Response - Canis familiaris [Pathway:R-RNO-5693606] DNA Double Strand Break Response - Rattus norvegicus
previousReviewStatus	[ReviewStatus:9821382] five stars
releaseDate	2015-09-22
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693179] Borowiec, James A, 2015-06-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5693606
summation	[Summation:5687762] DNA double-strand break (DSB) response involves sensing of D...
updateTrackers	[UpdateTracker:9783325] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v57:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776574] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v75:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775914] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v78:[modifyText, updateIndirectRLE] [UpdateTracker:9846644] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v84:[updateIndirectRLE]

Referrals

(updatedInstance)	[UpdateTracker:9783325] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v57:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9776574] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v75:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9775914] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v78:[modifyText, updateIndirectRLE] [UpdateTracker:9846644] Update Tracker - [Pathway:5693606] DNA Double Strand Break Response - v84:[updateIndirectRLE]
(replacementInstances)	[Deleted:6793413] Deletion of instance: 5685940
(normalPathway)	[Pathway:R-HSA-9699150] Defective DNA double strand break response due to BARD1 loss of function [Pathway:R-HSA-9663199] Defective DNA double strand break response due to BRCA1 loss of function
(hasEncapsulatedEvent)	[Pathway:R-HSA-69620] Cell Cycle Checkpoints [Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 [Pathway:R-HSA-6806003] Regulation of TP53 Expression and Degradation [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) [Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) [Pathway:R-HSA-5685939] HDR through MMEJ (alt-NHEJ)
(hasEvent)	[Pathway:R-HSA-5693532] DNA Double-Strand Break Repair
(precedingEvent)	[Pathway:R-HSA-5693571] Nonhomologous End-Joining (NHEJ) [Pathway:R-HSA-5693567] HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

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