Reactome | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

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Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10825173
displayName	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
eventOf	[Pathway:R-GGA-5693606] DNA Double Strand Break Response - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-GGA-5693598] ATM phosphorylates NBN - Gallus gallus [Reaction:R-GGA-5683930] WICH phosphorylates H2AFX on Y142 - Gallus gallus [Reaction:R-GGA-5693602] ATM recognizes H2AFX-Nucleosomes - Gallus gallus [Reaction:R-GGA-5693549] ATM phosphorylates histone H2AFX on S139 at DNA DSBs - Gallus gallus [Reaction:R-GGA-5683986] APBB1 and MAPK8 bind diphosphorylated H2AFX - Gallus gallus [Reaction:R-GGA-5683964] ATM phosphorylates EYA1-4 - Gallus gallus [Reaction:R-GGA-5683967] EYA1-4 dephosphorylates tyrosine Y142 of H2AFX - Gallus gallus [Reaction:R-GGA-5693536] ATM phosphorylates MDC1 - Gallus gallus [Reaction:R-GGA-5682967] WHSC1 binds DNA DSBs - Gallus gallus [Reaction:R-GGA-5682983] ATM phosphorylates WHSC1 - Gallus gallus [Reaction:R-GGA-5682965] WHSC1 dimethylates histone H4 on lysine K21 at DSBs - Gallus gallus [Reaction:R-GGA-5682992] KDM4A,B bind H4K20Me2 - Gallus gallus [Reaction:R-GGA-5682588] RNF8 binds phosphorylated MDC1 at DNA DSBs - Gallus gallus [Reaction:R-GGA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Gallus gallus [Reaction:R-GGA-5682598] ATM phosphorylates HERC2 - Gallus gallus [Reaction:R-GGA-5682607] PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs - Gallus gallus [Reaction:R-GGA-5682629] HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 - Gallus gallus [Reaction:R-GGA-5682863] RNF168 binds DNA DSBs - Gallus gallus [Reaction:R-GGA-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Gallus gallus [Reaction:R-GGA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Gallus gallus [Reaction:R-GGA-5693566] TP53BP1 associates with H4K20Me2 at DNA DSBs - Gallus gallus [Reaction:R-GGA-5683425] ATM phosphorylates TP53BP1 at DNA DSBs - Gallus gallus [Reaction:R-GGA-5683384] UIMC1 and FAM175A bind DNA DSBs - Gallus gallus [Reaction:R-GGA-5659781] BRCA1 forms a heterodimer with BARD1 - Gallus gallus [Reaction:R-GGA-9701000] BRCA1:BARD1 heterodimer autoubiquitinates - Gallus gallus [Reaction:R-GGA-9701003] BAP1 binds BRCA1:BARD1 heterodimer - Gallus gallus [Reaction:R-GGA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer - Gallus gallus [Reaction:R-GGA-5683385] Formation of BRCA1-A complex at DNA DSBs - Gallus gallus [Reaction:R-GGA-5693551] Phosphorylation of BRCA1-A complex at multiple sites by ATM - Gallus gallus [Reaction:R-GGA-5683735] CHEK2 is recruited to DNA DSBs - Gallus gallus [Reaction:R-GGA-69891] Phosphorylation and activation of CHEK2 by ATM - Gallus gallus [Reaction:R-GGA-5683774] p-T68-CHEK2 dimerizes - Gallus gallus [Reaction:R-GGA-5683792] p-T68-CHEK2 autophosphorylates - Gallus gallus [Reaction:R-GGA-5683801] CHEK2 phosphorylates BRCA1 - Gallus gallus [Reaction:R-GGA-5686578] Activated ATM phosphorylates ABL1 - Gallus gallus
inferredFrom	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
precedingEvent	[Pathway:R-GGA-5693548] Sensing of DNA Double Strand Breaks - Gallus gallus [Reaction:R-GGA-5693540] MRN activates ATM - Gallus gallus
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49591] Gallus gallus
stId	R-GGA-5693565
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-5693606] DNA Double Strand Break Response
(inferredTo)	[Pathway:R-HSA-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

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