Reactome | AKT1 E17K mutant phosphorylates forkhead box transcription factors

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AKT1 E17K mutant phosphorylates forkhead box transcription factors Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2399993] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2399987] Orlic-Milacic, M, 2012-07-13
dbId	2399992
disease	[Disease:1500689] cancer
displayName	AKT1 E17K mutant phosphorylates forkhead box transcription factors
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400003] gain_of_function of p-T308,S473-AKT1 E17K [nucleoplasm]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-199272] FOXO1,FOXO3,FOXO4,(FOXO6) [nucleoplasm]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:199294] Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B [LiteratureReference:199277] Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor [LiteratureReference:199313] Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant phosphorylates forkhead box transcription factors
normalReaction	[Reaction:R-HSA-199299] AKT phosphorylates FOXO transcription factors
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-9614997] p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4,(p-T26,S184-FOXO6) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2399992
summation	[Summation:2400000] AKT1 E17K gain-of-function mutant phosphorylates FOXO3 (Carp...

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(hasEvent)

[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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