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Schema
>
Reaction
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Entries
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
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authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
crossReference
[DatabaseIdentifier:12020752] Mondo:0005575
dbId
2243937
disease
[Disease:1500576] breast cancer
[Disease:1500689] cancer
[Disease:1248674] large intestine cancer
[Disease:1500575] ovarian cancer
displayName
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
edited
[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus
[EntityFunctionalStatus:3080615] gain_of_function of p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
eventOf
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
followingEvent
[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
input
[Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
[Complex:R-HSA-2219520] PDPK1:PIP2 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
[LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
[LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
output
[Complex:R-HSA-2243941] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex - Homo sapiens
[Reaction:R-HSA-2219524] PDPK1 binds PIP2 - Homo sapiens
releaseDate
2012-09-18
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13
[InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2243937
summation
[Summation:2243933] A portion of PDPK1 (PDK1) is anchored to the plasma membrane...
Referrals
(hasEvent)
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer
(precedingEvent)
[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant
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