Reactome | AKT1 E17K mutant phosphorylates TSC2, inhibiting it

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AKT1 E17K mutant phosphorylates TSC2, inhibiting it Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2399979] Orlic-Milacic, M, 2012-07-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2399982
disease	[Disease:1500689] cancer
displayName	AKT1 E17K mutant phosphorylates TSC2, inhibiting it
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-2980548] TSC2 [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:199381] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling [LiteratureReference:199857] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant phosphorylates TSC2, inhibiting it
normalReaction	[Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-199484] p-S939,T1462-TSC2 [cytosol]
precedingEvent	[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2399982
summation	[Summation:2399980] AKT1 E17K gain-of-function mutant is expected to phosphoryla...
updateTrackers	[UpdateTracker:9787553] Update Tracker - [Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - v44:[add_removeInput]

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(updatedInstance)	[UpdateTracker:9787553] Update Tracker - [Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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