Reactome | AKT1 E17K mutant phosphorylates BAD

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AKT1 E17K mutant phosphorylates BAD Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2399967] Orlic-Milacic, M, 2012-07-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2399941
disease	[Disease:1500689] cancer
displayName	AKT1 E17K mutant phosphorylates BAD
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-50662] BAD [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2399964] Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells [LiteratureReference:199394] Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant phosphorylates BAD
normalReaction	[Reaction:R-HSA-198347] AKT phosphorylates BAD
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-198335] p-S99-BAD [cytosol]
precedingEvent	[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2399941
summation	[Summation:2399936] AKT1 E17K gain-of-function mutant phosphorylates BAD (Guo et...

Referrals

(hasEvent)

[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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