Reactome | AKT inhibitors block AKT membrane recruitment

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AKT inhibitors block AKT membrane recruitment Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2400005] Orlic-Milacic, M, 2012-07-13
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	2400010
disease	[Disease:1500689] cancer
displayName	AKT inhibitors block AKT membrane recruitment
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input	[DefinedSet:R-ALL-2399923] AKT inhibitors [cytosol] [CandidateSet:R-HSA-2400013] AKT/AKT1 E17K mutant [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2399918] Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation [LiteratureReference:2404237] First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors [LiteratureReference:2404210] The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane [LiteratureReference:2399870] Targeting the phosphoinositide 3-kinase pathway in cancer
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT inhibitors block AKT membrane recruitment
output	[Complex:R-HSA-2400006] AKT inhibitors:AKT [cytosol]
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2400010
summation	[Summation:2404224] AKT inhibitors bind AKT and prevent its association with the...

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(hasEvent)

[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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