Reactome | AKT1 E17K mutant phosphorylates caspase-9

Schema > Reaction > Entries

AKT1 E17K mutant phosphorylates caspase-9 Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2399987] Orlic-Milacic, M, 2012-07-13
dbId	2399985
disease	[Disease:1500689] cancer
displayName	AKT1 E17K mutant phosphorylates caspase-9
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-57033] CASP9(1-416) [cytosol]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:199348] Regulation of cell death protease caspase-9 by phosphorylation
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant phosphorylates caspase-9
normalReaction	[Reaction:R-HSA-198621] AKT phosphorylates caspase-9
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-198636] p-S196-CASP9(1-416) [cytosol]
precedingEvent	[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2399985
summation	[Summation:2399991] AKT1 E17K gain-of-function mutant is expected to phosphoryla...

Referrals

(hasEvent)

[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

Cite Us!