Reactome | AKT1 E17K mutant is phosphorylated by TORC2 complex

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AKT1 E17K mutant is phosphorylated by TORC2 complex Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:198624] protein serine/threonine kinase activity of mTORC2:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	2243938
disease	[Disease:1500689] cancer [Disease:1500576] breast cancer [Disease:1248674] large intestine cancer [Disease:1500575] ovarian cancer
displayName	AKT1 E17K mutant is phosphorylated by TORC2 complex
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:3080617] gain_of_function of AKT1 E17K mutant:PIP2 [plasma membrane]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
followingEvent	[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
input	[Complex:R-HSA-2219527] AKT1 E17K mutant:PIP2 [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AKT1 E17K mutant is phosphorylated by TORC2 complex
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2243938
summation	[Summation:2243939] PIP2-binding AKT1 E17K mutants are anchored to the plasma m...

Referrals

(precedingEvent)	[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
(hasEvent)	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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