Reactome | PDPK1 phosphorylates AKT1 E17K mutant

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PDPK1 phosphorylates AKT1 E17K mutant Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2243940] protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2243934] Orlic-Milacic, M, 2012-05-09
crossReference	[DatabaseIdentifier:12020752] Mondo:0005575
dbId	2243942
disease	[Disease:1500576] breast cancer [Disease:1500689] cancer [Disease:1248674] large intestine cancer [Disease:1500575] ovarian cancer
displayName	PDPK1 phosphorylates AKT1 E17K mutant
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:3080614] gain_of_function of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
eventOf	[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
followingEvent	[Reaction:R-HSA-2399966] AKT1 E17K mutant phosphorylates GSK3 - Homo sapiens [Reaction:R-HSA-2399985] AKT1 E17K mutant phosphorylates caspase-9 - Homo sapiens [Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens [Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens [Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens [Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2 - Homo sapiens [Reaction:R-HSA-2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) - Homo sapiens [Reaction:R-HSA-2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 - Homo sapiens [Reaction:R-HSA-2399941] AKT1 E17K mutant phosphorylates BAD - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2243941] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain [LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PDPK1 phosphorylates AKT1 E17K mutant
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-2243935] p-T308,S473-AKT1 E17K [cytosol] [Complex:R-HSA-2219520] PDPK1:PIP2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2243942
summation	[Summation:2243936] PIP2-bound AKT1 E17K mutant is constitutively phosphorylated...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer

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