Reactome | PI3K binds ICOS

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PI3K binds ICOS Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19 [InstanceEdit:9927528] Garapati, Phani Vijay, 2024-11-07
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:388834] Garapati, P V, 2008-12-16 11:22:12
dbId	388830
displayName	PI3K binds ICOS
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-9927354] Co-stimulation by ICOS - Homo sapiens
followingEvent	[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[CandidateSet:R-HSA-9927349] Class 1A PI3Ks [cytosol] [EntityWithAccessionedSequence:R-HSA-389927] p-Y180-ICOS [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:388700] A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS)
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PI3K binds ICOS
orthologousEvent	[Reaction:R-BTA-388830] PI3K binds ICOS - Bos taurus [Reaction:R-GGA-388830] PI3K binds ICOS - Gallus gallus [Reaction:R-XTR-388830] PI3K binds ICOS - Xenopus tropicalis [Reaction:R-SSC-388830] PI3K binds ICOS - Sus scrofa [Reaction:R-CFA-388830] PI3K binds ICOS - Canis familiaris [Reaction:R-RNO-388830] PI3K binds ICOS - Rattus norvegicus [Reaction:R-MMU-388830] PI3K binds ICOS - Mus musculus
output	[Complex:R-HSA-388785] ICOS:PI3K [plasma membrane]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[PositiveRegulation:R-HSA-9031652] Positive regulation by 'ICOS:ICOSL [plasma membrane]'
regulationReference	[RegulationReference:9642610] Positive regulation by 'ICOS:ICOSL [plasma membrane]' ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 [InstanceEdit:9927531] Matthews, Lisa, 2024-11-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-388830
summation	[Summation:388730] ICOS ligation in T cells triggers the recruitment of PI3K, l...
updateTrackers	[UpdateTracker:9928430] Update Tracker - [Reaction:388830] PI3K binds ICOS - v91:[add_removeInput, modifyText] [UpdateTracker:9780097] Update Tracker - [Reaction:388830] PI3K binds ICOS - v64:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9928430] Update Tracker - [Reaction:388830] PI3K binds ICOS - v91:[add_removeInput, modifyText] [UpdateTracker:9780097] Update Tracker - [Reaction:388830] PI3K binds ICOS - v64:[addRegulator]
(hasEvent)	[Pathway:R-HSA-9927354] Co-stimulation by ICOS
(precedingEvent)	[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3