Reactome | Activated NTRK2 recruits PI3K

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Activated NTRK2 recruits PI3K Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9028506] Orlic-Milacic, Marija, 2017-11-08
dbId	9028505
displayName	Activated NTRK2 recruits PI3K
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9028335] Activated NTRK2 signals through PI3K - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3 - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9031077] Activated Ntrk2 recruits PI3K - Homo sapiens [BlackBoxEvent:R-MMU-9031076] Activated Ntrk2 recruits Gab1 - Mus musculus
input	[DefinedSet:R-HSA-9026521] BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] [Complex:R-HSA-179849] GRB2:GAB1 [cytosol] [Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9865786] Orlic-Milacic, Marija, 2024-03-18
name	Activated NTRK2 recruits PI3K
negativePrecedingEvent	[NegativePrecedingEvent:9865781] Futile Cycle: Activated PCLG1 dissociates from NTRK2
output	[Complex:R-HSA-9028508] BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens [Reaction:R-HSA-9026510] NTF4-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9028505
summation	[Summation:9028520] Activated NTRK2 (TRKB) receptor co-immunoprecipitates with t...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3 [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3
(hasEvent)	[Pathway:R-HSA-9028335] Activated NTRK2 signals through PI3K
(inferredTo)	[BlackBoxEvent:R-MMU-9031076] Activated Ntrk2 recruits Gab1 [BlackBoxEvent:R-NUL-9031077] Activated Ntrk2 recruits PI3K

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