Reactome | Dissociation of phosphorylated MAP2Ks and MAPKs

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Dissociation of phosphorylated MAP2Ks and MAPKs Show undefined attributes

authored	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
dbId	9610154
displayName	Dissociation of phosphorylated MAP2Ks and MAPKs
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
input	[Complex:R-HSA-9610140] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9610074] Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor [LiteratureReference:9610087] Signaling pathways for PC12 cell differentiation: making the right connections [LiteratureReference:9610094] Transcription factors and effectors that regulate neuronal morphology
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Dissociation of phosphorylated MAP2Ks and MAPKs
orthologousEvent	[BlackBoxEvent:R-CEL-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Caenorhabditis elegans [BlackBoxEvent:R-DME-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Drosophila melanogaster [BlackBoxEvent:R-DRE-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Danio rerio [BlackBoxEvent:R-SSC-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Sus scrofa [BlackBoxEvent:R-BTA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Bos taurus [BlackBoxEvent:R-RNO-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Rattus norvegicus [BlackBoxEvent:R-MMU-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Mus musculus
output	[DefinedSet:R-HSA-5672721] p-2S MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169289] p-T,Y MAPKs [cytosol] [Complex:R-HSA-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
precedingEvent	[Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9658256] D'Eustachio, Peter, 2019-08-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9610154
summation	[Summation:9610164] The mechanisms governing dissocation of activated signaling ...

Referrals

(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize [NegativePrecedingEvent:9865769] Futile Cycle: Dissociation of phosphorylated MAP2Ks and MAPKs