Reactome | Activated BRAF recruits MAP2Ks and MAPKs to the endosome

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Activated BRAF recruits MAP2Ks and MAPKs to the endosome Show undefined attributes

authored	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
dbId	9610152
displayName	Activated BRAF recruits MAP2Ks and MAPKs to the endosome
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
input	[DefinedSet:R-HSA-5672716] MAP2K homo/heterodimers [cytosol] [DefinedSet:R-HSA-169291] MAPKs [cytosol] [Complex:R-HSA-9610130] RAP1:GTP:activated BRAF dimer [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor [LiteratureReference:9610088] The neurotrophin receptor signaling endosome: Where trafficking meets signaling [LiteratureReference:205022] Neurotrophin-regulated signalling pathways
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Activated BRAF recruits MAP2Ks and MAPKs to the endosome
negativePrecedingEvent	[NegativePrecedingEvent:9865769] Futile Cycle: Dissociation of phosphorylated MAP2Ks and MAPKs
orthologousEvent	[Reaction:R-CEL-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Caenorhabditis elegans [Reaction:R-DME-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Drosophila melanogaster [Reaction:R-DRE-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Danio rerio [Reaction:R-SSC-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Sus scrofa [Reaction:R-BTA-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Bos taurus [Reaction:R-RNO-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Rattus norvegicus [Reaction:R-MMU-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Mus musculus
output	[Complex:R-HSA-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9658256] D'Eustachio, Peter, 2019-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9610152
summation	[Summation:9610161] Downstream of NGF stimulation and RAP1 activation, BRAF recr...

Referrals

(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF

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