Reactome | Frs2-mediated activation

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Frs2-mediated activation Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099395
displayName	Frs2-mediated activation
eventOf	[Pathway:R-MMU-169893] Prolonged ERK activation events - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-170964] FRS2 binds to active TrkA receptor - Mus musculus [Reaction:R-MMU-170977] FRS2 is phosphorylated by active TrkA receptor - Mus musculus [Reaction:R-MMU-170978] p-FRS2:CRKL binds C3G - Mus musculus [Reaction:R-MMU-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Mus musculus [Reaction:R-MMU-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Mus musculus [Reaction:R-MMU-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Mus musculus [Reaction:R-MMU-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Mus musculus [BlackBoxEvent:R-MMU-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Mus musculus [Reaction:R-MMU-5674385] p-T,Y MAPKs dimerize - Mus musculus [BlackBoxEvent:R-MMU-9610166] p-T,Y MAPK dimers translocate to nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Frs2-mediated activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-170968
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-169893] Prolonged ERK activation events
(inferredTo)	[Pathway:R-HSA-170968] Frs2-mediated activation

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