Reactome | FRS2 binds to active TrkA receptor

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FRS2 binds to active TrkA receptor Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
dbId	170964
displayName	FRS2 binds to active TrkA receptor
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-170977] FRS2 is phosphorylated by active TrkA receptor - Homo sapiens
input	[Complex:R-HSA-190083] Activated TrkA receptor complex [endosome membrane] [EntityWithAccessionedSequence:R-HSA-190244] FRS2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182133] FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	FRS2 binds to active TrkA receptor
orthologousEvent	[Reaction:R-GGA-170964] FRS2 binds to active TrkA receptor - Gallus gallus [Reaction:R-XTR-170964] FRS2 binds to active TrkA receptor - Xenopus tropicalis [Reaction:R-DRE-170964] FRS2 binds to active TrkA receptor - Danio rerio [Reaction:R-SSC-170964] FRS2 binds to active TrkA receptor - Sus scrofa [Reaction:R-BTA-170964] FRS2 binds to active TrkA receptor - Bos taurus [Reaction:R-CFA-170964] FRS2 binds to active TrkA receptor - Canis familiaris [Reaction:R-RNO-170964] FRS2 binds to active TrkA receptor - Rattus norvegicus [Reaction:R-MMU-170964] FRS2 binds to active TrkA receptor - Mus musculus
output	[Complex:R-HSA-190068] Active TrkA receptor:FRS2 complex [endosome membrane]
precedingEvent	[BlackBoxEvent:R-HSA-190065] Activated TrkA receptor internalizes to endosomes - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170964
summation	[Summation:187731] FRS2 binds to TRKA through the same motif (NPXY) around the ...
updateTrackers	[UpdateTracker:9778998] Update Tracker - [Reaction:170964] FRS2 binds to active TrkA receptor - v66:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778998] Update Tracker - [Reaction:170964] FRS2 binds to active TrkA receptor - v66:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-170977] FRS2 is phosphorylated by active TrkA receptor