Reactome | (Frs2)C3G stimulates nucleotide exchange on Rap1

Schema > Reaction > Entries

(Frs2)C3G stimulates nucleotide exchange on Rap1 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:170980] guanyl-nucleotide exchange factor activity of Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane]
category	transition
compartment	[Compartment:17940] endosome
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
dbId	170979
displayName	(Frs2)C3G stimulates nucleotide exchange on Rap1
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf - Homo sapiens
inferredFrom	[Reaction:R-RNO-182053] C3G stimulates nucleotide exchange on Rap1 - Rattus norvegicus
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-190077] RAP1:GDP [endosome membrane]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	(Frs2)C3G stimulates nucleotide exchange on Rap1
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-190069] RAP1:GTP [endosome membrane]
precedingEvent	[Reaction:R-HSA-170978] p-FRS2:CRKL binds C3G - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170979
summation	[Summation:187780] Rap1 is a small G protein, necessary for prolonged ERK activ...

Referrals

(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-170965] (Frs2)Rap1-GTP binds to and activates B-Raf
(inferredTo)	[Reaction:R-RNO-182053] C3G stimulates nucleotide exchange on Rap1

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