Reactome | p-T,Y MAPK dimers translocate to nucleus

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p-T,Y MAPK dimers translocate to nucleus Show undefined attributes

authored	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
dbId	9610166
displayName	p-T,Y MAPK dimers translocate to nucleus
edited	[InstanceEdit:9610183] Rothfels, Karen, 2018-06-05
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) - Homo sapiens [Reaction:R-HSA-199959] ERKs are inactivated by protein phosphatase 2A - Homo sapiens [Reaction:R-HSA-198731] ERK1/2 activates ELK1 - Homo sapiens [Reaction:R-HSA-198756] ERK1/2 phosphorylates MSK1 - Homo sapiens [Reaction:R-HSA-198746] ERK1/2/5 activate RSK1/2/3 - Homo sapiens
input	[DefinedSet:R-HSA-1268261] p-T,Y MAPK dimers [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9031578] Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation [LiteratureReference:9610764] Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells [LiteratureReference:9610094] Transcription factors and effectors that regulate neuronal morphology [LiteratureReference:5674347] ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task [LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	p-T,Y MAPK dimers translocate to nucleus
orthologousEvent	[BlackBoxEvent:R-DDI-9610166] p-T,Y MAPK dimers translocate to nucleus - Dictyostelium discoideum [BlackBoxEvent:R-CEL-9610166] p-T,Y MAPK dimers translocate to nucleus - Caenorhabditis elegans [BlackBoxEvent:R-DME-9610166] p-T,Y MAPK dimers translocate to nucleus - Drosophila melanogaster [BlackBoxEvent:R-GGA-9610166] p-T,Y MAPK dimers translocate to nucleus - Gallus gallus [BlackBoxEvent:R-XTR-9610166] p-T,Y MAPK dimers translocate to nucleus - Xenopus tropicalis [BlackBoxEvent:R-DRE-9610166] p-T,Y MAPK dimers translocate to nucleus - Danio rerio [BlackBoxEvent:R-SSC-9610166] p-T,Y MAPK dimers translocate to nucleus - Sus scrofa [BlackBoxEvent:R-BTA-9610166] p-T,Y MAPK dimers translocate to nucleus - Bos taurus [BlackBoxEvent:R-CFA-9610166] p-T,Y MAPK dimers translocate to nucleus - Canis familiaris [BlackBoxEvent:R-RNO-9610166] p-T,Y MAPK dimers translocate to nucleus - Rattus norvegicus [BlackBoxEvent:R-MMU-9610166] p-T,Y MAPK dimers translocate to nucleus - Mus musculus
output	[DefinedSet:R-HSA-198701] p-T,Y MAPK dimers [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9610166
summation	[Summation:9610774] After phosphorylation by MAP2Ks, a proportion of activated M...

Referrals

(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) [Reaction:R-HSA-198731] ERK1/2 activates ELK1 [Reaction:R-HSA-199959] ERKs are inactivated by protein phosphatase 2A [Reaction:R-HSA-198746] ERK1/2/5 activate RSK1/2/3 [Reaction:R-HSA-198756] ERK1/2 phosphorylates MSK1

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