Reactome | Frs2-mediated activation

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Frs2-mediated activation Show undefined attributes

created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10739448
displayName	Frs2-mediated activation
eventOf	[Pathway:R-DME-169893] Prolonged ERK activation events - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DME-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Drosophila melanogaster [Reaction:R-DME-9610152] Activated BRAF recruits MAP2Ks and MAPKs to the endosome - Drosophila melanogaster [Reaction:R-DME-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Drosophila melanogaster [Reaction:R-DME-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Drosophila melanogaster [BlackBoxEvent:R-DME-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Drosophila melanogaster [Reaction:R-DME-5674385] p-T,Y MAPKs dimerize - Drosophila melanogaster [BlackBoxEvent:R-DME-9610166] p-T,Y MAPK dimers translocate to nucleus - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
isInDisease	false
isInferred	true
name	Frs2-mediated activation
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-170968
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-169893] Prolonged ERK activation events
(inferredTo)	[Pathway:R-HSA-170968] Frs2-mediated activation

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