Reactome | p-FRS2:CRKL binds C3G

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p-FRS2:CRKL binds C3G Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
category	binding
compartment	[Compartment:74700] endosome membrane
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
dbId	170978
displayName	p-FRS2:CRKL binds C3G
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - Homo sapiens
input	[Complex:R-HSA-190081] Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] [EntityWithAccessionedSequence:R-HSA-913472] RAPGEF1 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:187775] Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk [LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	p-FRS2:CRKL binds C3G
orthologousEvent	[Reaction:R-GGA-170978] p-FRS2:CRKL binds C3G - Gallus gallus [Reaction:R-XTR-170978] p-FRS2:CRKL binds C3G - Xenopus tropicalis [Reaction:R-SSC-170978] p-FRS2:CRKL binds C3G - Sus scrofa [Reaction:R-BTA-170978] p-FRS2:CRKL binds C3G - Bos taurus [Reaction:R-CFA-170978] p-FRS2:CRKL binds C3G - Canis familiaris [Reaction:R-RNO-170978] p-FRS2:CRKL binds C3G - Rattus norvegicus [Reaction:R-MMU-170978] p-FRS2:CRKL binds C3G - Mus musculus
output	[Complex:R-HSA-190070] Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane]
precedingEvent	[Reaction:R-HSA-170975] p-FRS2 binds CRKL - Homo sapiens
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-170978
summation	[Summation:187779] Rap guanine nucleotide exchange factor 1 (RAPGEF1, C3G) is a...
updateTrackers	[UpdateTracker:9791801] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v25:[modifyText] [UpdateTracker:9787864] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v44:[add_removeInput] [UpdateTracker:9780393] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v63:[modifyText] [UpdateTracker:9779246] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v66:[addLiteratureReference, add_removeInput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791801] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v25:[modifyText] [UpdateTracker:9787864] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v44:[add_removeInput] [UpdateTracker:9780393] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v63:[modifyText] [UpdateTracker:9779246] Update Tracker - [Reaction:170978] p-FRS2:CRKL binds C3G - v66:[addLiteratureReference, add_removeInput, modifyText]
(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[Reaction:R-HSA-170979] (Frs2)C3G stimulates nucleotide exchange on Rap1

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