Reactome | MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF

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MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF Show undefined attributes

authored	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
catalystActivity	[CatalystActivity:9610157] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
dbId	9610156
displayName	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
eventOf	[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9610136] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182076] Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells [LiteratureReference:182096] Nerve growth factor activates persistent Rap1 signaling in endosomes [LiteratureReference:189687] Trk receptors: roles in neuronal signal transduction [LiteratureReference:205022] Neurotrophin-regulated signalling pathways
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
orthologousEvent	[Reaction:R-DDI-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Dictyostelium discoideum [Reaction:R-CEL-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Caenorhabditis elegans [Reaction:R-DME-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Drosophila melanogaster [Reaction:R-DRE-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Danio rerio [Reaction:R-SSC-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Sus scrofa [Reaction:R-BTA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Bos taurus [Reaction:R-RNO-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Rattus norvegicus [Reaction:R-MMU-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9610140] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane]
precedingEvent	[Reaction:R-HSA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Homo sapiens
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9658256] D'Eustachio, Peter, 2019-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9610156
summation	[Summation:9610160] Activated MAP2K1 and MAP2K2 dimers phosphorylate MAPK1 and M...

Referrals

(hasEvent)	[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)	[BlackBoxEvent:R-HSA-9610154] Dissociation of phosphorylated MAP2Ks and MAPKs