Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
Show undefined attributes
Go to Details
authored
[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
catalystActivity
[CatalystActivity:9610155] protein serine/threonine kinase activity of RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
category
transition
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
dbId
9610153
displayName
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
eventOf
[Pathway:R-HSA-170968] Frs2-mediated activation - Homo sapiens
followingEvent
[Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9610134] RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
[LiteratureReference:182076] Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
[LiteratureReference:189687] Trk receptors: roles in neuronal signal transduction
[LiteratureReference:205022] Neurotrophin-regulated signalling pathways
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
orthologousEvent
[Reaction:R-CEL-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Caenorhabditis elegans
[Reaction:R-DME-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Drosophila melanogaster
[Reaction:R-GGA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Gallus gallus
[Reaction:R-DRE-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Danio rerio
[Reaction:R-SSC-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Sus scrofa
[Reaction:R-BTA-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Bos taurus
[Reaction:R-RNO-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Rattus norvegicus
[Reaction:R-MMU-9610153] Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-9610136] RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane]
precedingEvent
[Reaction:R-HSA-9610163] BRAF autophosphorylates downstream of RAP1 and NGF - Homo sapiens
releaseDate
2019-09-10
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9658256] D'Eustachio, Peter, 2019-08-12
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9610153
summation
[Summation:9610151] Downstream of NGF stimulation, activated BRAF phosphorylates...
Referrals
(hasEvent)
[Pathway:R-HSA-170968] Frs2-mediated activation
(precedingEvent)
[Reaction:R-HSA-9610156] MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text