Reactome | Innate Immune System

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Innate Immune System Show undefined attributes

created	[InstanceEdit:168250] Gillespie, ME, 2005-11-11 22:06:24
dbId	168249
displayName	Innate Immune System
doi	10.3180/REACT_6802.2
eventOf	[TopLevelPathway:R-HSA-168256] Immune System - Homo sapiens
figure	[Figure:9628883] /figures/ehld/R-HSA-168249.svg
goBiologicalProcess	[GO_BiologicalProcess:408] innate immune response
hasDiagram	true
hasEHLD	true
hasEvent	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens [Pathway:R-HSA-166658] Complement cascade - Homo sapiens [Pathway:R-HSA-168643] Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways - Homo sapiens [Pathway:R-HSA-879415] Advanced glycosylation endproduct receptor signaling - Homo sapiens [Pathway:R-HSA-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Homo sapiens [Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens [Pathway:R-HSA-2029480] Fcgamma receptor (FCGR) dependent phagocytosis - Homo sapiens [Pathway:R-HSA-2172127] DAP12 interactions - Homo sapiens [Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling - Homo sapiens [Pathway:R-HSA-5621481] C-type lectin receptors (CLRs) - Homo sapiens [Pathway:R-HSA-6803157] Antimicrobial peptides - Homo sapiens [Pathway:R-HSA-6798695] Neutrophil degranulation - Homo sapiens [Pathway:R-HSA-1222556] ROS and RNS production in phagocytes - Homo sapiens [Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens [Pathway:R-HSA-9686114] Non-canonical inflammasome activation - Homo sapiens [Pathway:R-HSA-9970672] FXIIa activates plasma kallikrein-kinin system - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
maxDepth	10
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Innate Immune System
orthologousEvent	[Pathway:R-CFA-168249] Innate Immune System - Canis familiaris [Pathway:R-BTA-168249] Innate Immune System - Bos taurus [Pathway:R-SSC-168249] Innate Immune System - Sus scrofa [Pathway:R-DRE-168249] Innate Immune System - Danio rerio [Pathway:R-XTR-168249] Innate Immune System - Xenopus tropicalis [Pathway:R-GGA-168249] Innate Immune System - Gallus gallus [Pathway:R-CEL-168249] Innate Immune System - Caenorhabditis elegans [Pathway:R-SPO-168249] Innate Immune System - Schizosaccharomyces pombe [Pathway:R-SCE-168249] Innate Immune System - Saccharomyces cerevisiae [Pathway:R-DME-168249] Innate Immune System - Drosophila melanogaster [Pathway:R-DDI-168249] Innate Immune System - Dictyostelium discoideum [Pathway:R-PFA-168249] Innate Immune System - Plasmodium falciparum [Pathway:R-RNO-168249] Innate Immune System - Rattus norvegicus [Pathway:R-MMU-168249] Innate Immune System - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-06-13
releaseStatus	UPDATED
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9981575] Matthews, Lisa, 2026-02-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168249
summation	[Summation:210930] Innate immunity encompases the nonspecific part of immunity ...
updateTrackers	[UpdateTracker:9790294] Update Tracker - [Pathway:168249] Innate Immune System - v34:[updateContainedPathway] [UpdateTracker:9778758] Update Tracker - [Pathway:168249] Innate Immune System - v67:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782671] Update Tracker - [Pathway:168249] Innate Immune System - v59:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787005] Update Tracker - [Pathway:168249] Innate Immune System - v46:[updateContainedPathway] [UpdateTracker:9776853] Update Tracker - [Pathway:168249] Innate Immune System - v74:[updateContainedPathway] [UpdateTracker:9788505] Update Tracker - [Pathway:168249] Innate Immune System - v41:[updateContainedPathway] [UpdateTracker:9788917] Update Tracker - [Pathway:168249] Innate Immune System - v39:[addHasEvent] [UpdateTracker:9779841] Update Tracker - [Pathway:168249] Innate Immune System - v64:[updateIndirectRLE] [UpdateTracker:9789975] Update Tracker - [Pathway:168249] Innate Immune System - v36:[updateContainedPathway] [UpdateTracker:9789115] Update Tracker - [Pathway:168249] Innate Immune System - v38:[updateContainedPathway] [UpdateTracker:9787359] Update Tracker - [Pathway:168249] Innate Immune System - v45:[addHasEvent, updateContainedPathway] [UpdateTracker:9780510] Update Tracker - [Pathway:168249] Innate Immune System - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784263] Update Tracker - [Pathway:168249] Innate Immune System - v54:[updateIndirectRLE] [UpdateTracker:9910942] Update Tracker - [Pathway:168249] Innate Immune System - v89:[updateContainedPathway] [UpdateTracker:9786485] Update Tracker - [Pathway:168249] Innate Immune System - v49:[updateContainedPathway] [UpdateTracker:9784748] Update Tracker - [Pathway:168249] Innate Immune System - v53:[updateContainedPathway] [UpdateTracker:9791082] Update Tracker - [Pathway:168249] Innate Immune System - v32:[updateContainedPathway] [UpdateTracker:9774635] Update Tracker - [Pathway:168249] Innate Immune System - v81:[updateContainedPathway] [UpdateTracker:9781911] Update Tracker - [Pathway:168249] Innate Immune System - v60:[updateContainedPathway] [UpdateTracker:9776024] Update Tracker - [Pathway:168249] Innate Immune System - v78:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9779307] Update Tracker - [Pathway:168249] Innate Immune System - v65:[updateContainedPathway] [UpdateTracker:9788786] Update Tracker - [Pathway:168249] Innate Immune System - v40:[addHasEvent, updateContainedPathway] [UpdateTracker:9776149] Update Tracker - [Pathway:168249] Innate Immune System - v77:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791760] Update Tracker - [Pathway:168249] Innate Immune System - v26:[updateContainedPathway] [UpdateTracker:9783308] Update Tracker - [Pathway:168249] Innate Immune System - v57:[updateContainedPathway] [UpdateTracker:9984606] Update Tracker - [Pathway:168249] Innate Immune System - v96:[removeHasEvent] [UpdateTracker:9788347] Update Tracker - [Pathway:168249] Innate Immune System - v42:[addHasEvent, updateContainedPathway] [UpdateTracker:9781362] Update Tracker - [Pathway:168249] Innate Immune System - v61:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790147] Update Tracker - [Pathway:168249] Innate Immune System - v35:[addHasEvent, updateContainedPathway] [UpdateTracker:9789538] Update Tracker - [Pathway:168249] Innate Immune System - v37:[addHasEvent, updateIndirectRLE] [UpdateTracker:9777616] Update Tracker - [Pathway:168249] Innate Immune System - v70:[addHasEvent, updateContainedPathway] [UpdateTracker:9777251] Update Tracker - [Pathway:168249] Innate Immune System - v72:[updateContainedPathway] [UpdateTracker:9791999] Update Tracker - [Pathway:168249] Innate Immune System - v24:[addSummation] [UpdateTracker:9786854] Update Tracker - [Pathway:168249] Innate Immune System - v47:[updateContainedPathway] [UpdateTracker:9782880] Update Tracker - [Pathway:168249] Innate Immune System - v58:[add_removeHasEvent] [UpdateTracker:9776958] Update Tracker - [Pathway:168249] Innate Immune System - v73:[updateContainedPathway] [UpdateTracker:9776442] Update Tracker - [Pathway:168249] Innate Immune System - v76:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783438] Update Tracker - [Pathway:168249] Innate Immune System - v56:[updateContainedPathway] [UpdateTracker:9842305] Update Tracker - [Pathway:168249] Innate Immune System - v86:[updateContainedPathway] [UpdateTracker:9784932] Update Tracker - [Pathway:168249] Innate Immune System - v52:[addHasEvent] [UpdateTracker:9788247] Update Tracker - [Pathway:168249] Innate Immune System - v43:[updateContainedPathway] [UpdateTracker:9864092] Update Tracker - [Pathway:168249] Innate Immune System - v88:[updateContainedPathway] [UpdateTracker:9780374] Update Tracker - [Pathway:168249] Innate Immune System - v63:[updateContainedPathway] [UpdateTracker:9787850] Update Tracker - [Pathway:168249] Innate Immune System - v44:[addHasEvent, updateIndirectRLE] [UpdateTracker:9775111] Update Tracker - [Pathway:168249] Innate Immune System - v80:[updateIndirectRLE] [UpdateTracker:9964649] Update Tracker - [Pathway:168249] Innate Immune System - v94:[removeHasEvent] [UpdateTracker:9846744] Update Tracker - [Pathway:168249] Innate Immune System - v84:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[TopLevelPathway:R-HSA-168256] Immune System
(hasEncapsulatedEvent)	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes
(updatedInstance)	[UpdateTracker:9790294] Update Tracker - [Pathway:168249] Innate Immune System - v34:[updateContainedPathway] [UpdateTracker:9778758] Update Tracker - [Pathway:168249] Innate Immune System - v67:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782671] Update Tracker - [Pathway:168249] Innate Immune System - v59:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787005] Update Tracker - [Pathway:168249] Innate Immune System - v46:[updateContainedPathway] [UpdateTracker:9776853] Update Tracker - [Pathway:168249] Innate Immune System - v74:[updateContainedPathway] [UpdateTracker:9788505] Update Tracker - [Pathway:168249] Innate Immune System - v41:[updateContainedPathway] [UpdateTracker:9788917] Update Tracker - [Pathway:168249] Innate Immune System - v39:[addHasEvent] [UpdateTracker:9779841] Update Tracker - [Pathway:168249] Innate Immune System - v64:[updateIndirectRLE] [UpdateTracker:9789975] Update Tracker - [Pathway:168249] Innate Immune System - v36:[updateContainedPathway] [UpdateTracker:9789115] Update Tracker - [Pathway:168249] Innate Immune System - v38:[updateContainedPathway] [UpdateTracker:9787359] Update Tracker - [Pathway:168249] Innate Immune System - v45:[addHasEvent, updateContainedPathway] [UpdateTracker:9780510] Update Tracker - [Pathway:168249] Innate Immune System - v62:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784263] Update Tracker - [Pathway:168249] Innate Immune System - v54:[updateIndirectRLE] [UpdateTracker:9910942] Update Tracker - [Pathway:168249] Innate Immune System - v89:[updateContainedPathway] [UpdateTracker:9786485] Update Tracker - [Pathway:168249] Innate Immune System - v49:[updateContainedPathway] [UpdateTracker:9784748] Update Tracker - [Pathway:168249] Innate Immune System - v53:[updateContainedPathway] [UpdateTracker:9791082] Update Tracker - [Pathway:168249] Innate Immune System - v32:[updateContainedPathway] [UpdateTracker:9774635] Update Tracker - [Pathway:168249] Innate Immune System - v81:[updateContainedPathway] [UpdateTracker:9781911] Update Tracker - [Pathway:168249] Innate Immune System - v60:[updateContainedPathway] [UpdateTracker:9776024] Update Tracker - [Pathway:168249] Innate Immune System - v78:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9779307] Update Tracker - [Pathway:168249] Innate Immune System - v65:[updateContainedPathway] [UpdateTracker:9788786] Update Tracker - [Pathway:168249] Innate Immune System - v40:[addHasEvent, updateContainedPathway] [UpdateTracker:9776149] Update Tracker - [Pathway:168249] Innate Immune System - v77:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9791760] Update Tracker - [Pathway:168249] Innate Immune System - v26:[updateContainedPathway] [UpdateTracker:9783308] Update Tracker - [Pathway:168249] Innate Immune System - v57:[updateContainedPathway] [UpdateTracker:9984606] Update Tracker - [Pathway:168249] Innate Immune System - v96:[removeHasEvent] [UpdateTracker:9788347] Update Tracker - [Pathway:168249] Innate Immune System - v42:[addHasEvent, updateContainedPathway] [UpdateTracker:9781362] Update Tracker - [Pathway:168249] Innate Immune System - v61:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9790147] Update Tracker - [Pathway:168249] Innate Immune System - v35:[addHasEvent, updateContainedPathway] [UpdateTracker:9789538] Update Tracker - [Pathway:168249] Innate Immune System - v37:[addHasEvent, updateIndirectRLE] [UpdateTracker:9777616] Update Tracker - [Pathway:168249] Innate Immune System - v70:[addHasEvent, updateContainedPathway] [UpdateTracker:9777251] Update Tracker - [Pathway:168249] Innate Immune System - v72:[updateContainedPathway] [UpdateTracker:9791999] Update Tracker - [Pathway:168249] Innate Immune System - v24:[addSummation] [UpdateTracker:9786854] Update Tracker - [Pathway:168249] Innate Immune System - v47:[updateContainedPathway] [UpdateTracker:9782880] Update Tracker - [Pathway:168249] Innate Immune System - v58:[add_removeHasEvent] [UpdateTracker:9776958] Update Tracker - [Pathway:168249] Innate Immune System - v73:[updateContainedPathway] [UpdateTracker:9776442] Update Tracker - [Pathway:168249] Innate Immune System - v76:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783438] Update Tracker - [Pathway:168249] Innate Immune System - v56:[updateContainedPathway] [UpdateTracker:9842305] Update Tracker - [Pathway:168249] Innate Immune System - v86:[updateContainedPathway] [UpdateTracker:9784932] Update Tracker - [Pathway:168249] Innate Immune System - v52:[addHasEvent] [UpdateTracker:9788247] Update Tracker - [Pathway:168249] Innate Immune System - v43:[updateContainedPathway] [UpdateTracker:9864092] Update Tracker - [Pathway:168249] Innate Immune System - v88:[updateContainedPathway] [UpdateTracker:9780374] Update Tracker - [Pathway:168249] Innate Immune System - v63:[updateContainedPathway] [UpdateTracker:9787850] Update Tracker - [Pathway:168249] Innate Immune System - v44:[addHasEvent, updateIndirectRLE] [UpdateTracker:9775111] Update Tracker - [Pathway:168249] Innate Immune System - v80:[updateIndirectRLE] [UpdateTracker:9964649] Update Tracker - [Pathway:168249] Innate Immune System - v94:[removeHasEvent] [UpdateTracker:9846744] Update Tracker - [Pathway:168249] Innate Immune System - v84:[updateContainedPathway, updateIndirectRLE]

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