Reactome | Toll Like Receptor 5 (TLR5) Cascade

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Toll Like Receptor 5 (TLR5) Cascade Show undefined attributes

authored	[InstanceEdit:167907] Luo, F, 2005-11-10 11:23:18
created	[InstanceEdit:168183] Gillespie, ME, 2005-11-10 16:33:34
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	168176
displayName	Toll Like Receptor 5 (TLR5) Cascade
edited	[InstanceEdit:1485578] Shamovsky, V, 2011-08-12
eventOf	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:260240] toll-like receptor 5 signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-188025] Flagellin binds to TLR5 - Homo sapiens [Pathway:R-HSA-975871] MyD88 cascade initiated on plasma membrane - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:188053] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 [LiteratureReference:188304] Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression [Book:1458605] Paul, W Innate Immune System Fundamental Immunology 0781735149
maxDepth	7
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Toll Like Receptor 5 (TLR5) Cascade
orthologousEvent	[Pathway:R-PFA-168176] Toll Like Receptor 5 (TLR5) Cascade - Plasmodium falciparum [Pathway:R-SCE-168176] Toll Like Receptor 5 (TLR5) Cascade - Saccharomyces cerevisiae [Pathway:R-SPO-168176] Toll Like Receptor 5 (TLR5) Cascade - Schizosaccharomyces pombe [Pathway:R-DDI-168176] Toll Like Receptor 5 (TLR5) Cascade - Dictyostelium discoideum [Pathway:R-CEL-168176] Toll Like Receptor 5 (TLR5) Cascade - Caenorhabditis elegans [Pathway:R-DME-168176] Toll Like Receptor 5 (TLR5) Cascade - Drosophila melanogaster [Pathway:R-GGA-168176] Toll Like Receptor 5 (TLR5) Cascade - Gallus gallus [Pathway:R-XTR-168176] Toll Like Receptor 5 (TLR5) Cascade - Xenopus tropicalis [Pathway:R-DRE-168176] Toll Like Receptor 5 (TLR5) Cascade - Danio rerio [Pathway:R-SSC-168176] Toll Like Receptor 5 (TLR5) Cascade - Sus scrofa [Pathway:R-BTA-168176] Toll Like Receptor 5 (TLR5) Cascade - Bos taurus [Pathway:R-CFA-168176] Toll Like Receptor 5 (TLR5) Cascade - Canis familiaris [Pathway:R-RNO-168176] Toll Like Receptor 5 (TLR5) Cascade - Rattus norvegicus [Pathway:R-MMU-168176] Toll Like Receptor 5 (TLR5) Cascade - Mus musculus
relatedSpecies	[Species:159879] Escherichia coli
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188962] Gale M, Jr, 2006-10-31 16:45:01 [InstanceEdit:1186998] Gillespie, ME, 2011-02-10
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-168176
summation	[Summation:188300] TLR5 is the receptor for flagellin, the protein that forms b...
updateTrackers	[UpdateTracker:9789911] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v36:[addHasEvent] [UpdateTracker:9790280] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v34:[removeHasEvent] [UpdateTracker:9788711] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v41:[updateIndirectRLE] [UpdateTracker:9775038] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v80:[updateContainedPathway] [UpdateTracker:9789220] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v38:[addLiteratureReference, modifyText, updateContainedPathway] [UpdateTracker:9788299] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v43:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785391] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v52:[updateContainedPathway] [UpdateTracker:9791822] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v25:[updateIndirectRLE] [UpdateTracker:9782176] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v59:[updateIndirectRLE] [UpdateTracker:9784739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v53:[updateContainedPathway] [UpdateTracker:9777889] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v68:[updateContainedPathway] [UpdateTracker:9786399] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v49:[updateContainedPathway] [UpdateTracker:9788408] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v42:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789710] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v37:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9784169] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v54:[updateContainedPathway] [UpdateTracker:9774739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v81:[updateContainedPathway] [UpdateTracker:9790459] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v33:[updateContainedPathway]

Referrals

(updatedInstance)

[UpdateTracker:9789911] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v36:[addHasEvent]
[UpdateTracker:9790280] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v34:[removeHasEvent]
[UpdateTracker:9788711] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v41:[updateIndirectRLE]
[UpdateTracker:9775038] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v80:[updateContainedPathway]
[UpdateTracker:9789220] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v38:[addLiteratureReference, modifyText, updateContainedPathway]
[UpdateTracker:9788299] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v43:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9785391] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v52:[updateContainedPathway]
[UpdateTracker:9791822] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v25:[updateIndirectRLE]
[UpdateTracker:9782176] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v59:[updateIndirectRLE]
[UpdateTracker:9784739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v53:[updateContainedPathway]
[UpdateTracker:9777889] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v68:[updateContainedPathway]
[UpdateTracker:9786399] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v49:[updateContainedPathway]
[UpdateTracker:9788408] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v42:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9789710] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v37:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9784169] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v54:[updateContainedPathway]
[UpdateTracker:9774739] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v81:[updateContainedPathway]
[UpdateTracker:9790459] Update Tracker - [Pathway:168176] Toll Like Receptor 5 (TLR5) Cascade - v33:[updateContainedPathway]

(hasEvent)

[Pathway:R-HSA-168898] Toll-like Receptor Cascades

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