Reactome | Regulation of TLR by endogenous ligand

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Regulation of TLR by endogenous ligand Show undefined attributes

authored	[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
created	[InstanceEdit:5686931] Shamovsky, Veronica, 2015-04-06
dbId	5686938
diseasePathways	[Pathway:R-HSA-9824856] Defective regulation of TLR7 by endogenous ligand - Homo sapiens
displayName	Regulation of TLR by endogenous ligand
doi	10.3180/R-HSA-5686938.1
edited	[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-6805981] HMGB1 release from cells - Homo sapiens [Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-6804100] HMGB1 binds LPS - Homo sapiens [Reaction:R-HSA-6804099] HMGB1 binds LTP - Homo sapiens [Reaction:R-HSA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Homo sapiens [Reaction:R-HSA-5432849] S100A8:S100A9 binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-6805943] S100A1 binds TLR4:LY96 - Homo sapiens [Reaction:R-HSA-8869694] oxPL binds CD14 - Homo sapiens [Reaction:R-HSA-8869683] oxPL binds LBP - Homo sapiens [Reaction:R-HSA-8869667] oxLDL:CD36 binds TLR4:TLR6 - Homo sapiens [Reaction:R-HSA-8870678] Cleaved fibrinogen products bind TLR4:LY96 - Homo sapiens [Reaction:R-HSA-9824732] G or G analog binds C-ter TLR7 dimer - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:5686934] DAMPening inflammation by modulating TLR signalling [LiteratureReference:6793749] Endogenous toll-like receptor ligands and their biological significance [LiteratureReference:6804095] Complexity of danger: the diverse nature of damage-associated molecular patterns [LiteratureReference:5686936] Endogenous ligands of TLR2 and TLR4: agonists or assistants?
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Regulation of TLR by endogenous ligand
orthologousEvent	[Pathway:R-RNO-5686938] Regulation of TLR by endogenous ligand - Rattus norvegicus [Pathway:R-CFA-5686938] Regulation of TLR by endogenous ligand - Canis familiaris [Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand - Bos taurus [Pathway:R-SSC-5686938] Regulation of TLR by endogenous ligand - Sus scrofa [Pathway:R-DRE-5686938] Regulation of TLR by endogenous ligand - Danio rerio [Pathway:R-XTR-5686938] Regulation of TLR by endogenous ligand - Xenopus tropicalis [Pathway:R-DDI-5686938] Regulation of TLR by endogenous ligand - Dictyostelium discoideum [Pathway:R-SPO-5686938] Regulation of TLR by endogenous ligand - Schizosaccharomyces pombe [Pathway:R-DME-5686938] Regulation of TLR by endogenous ligand - Drosophila melanogaster [Pathway:R-CEL-5686938] Regulation of TLR by endogenous ligand - Caenorhabditis elegans [Pathway:R-PFA-5686938] Regulation of TLR by endogenous ligand - Plasmodium falciparum [Pathway:R-SCE-5686938] Regulation of TLR by endogenous ligand - Saccharomyces cerevisiae [Pathway:R-GGA-5686938] Regulation of TLR by endogenous ligand - Gallus gallus [Pathway:R-MMU-5686938] Regulation of TLR by endogenous ligand - Mus musculus
releaseDate	2016-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12 [InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5686938
summation	[Summation:5686933] Diverse molecules of host-cell origin may serve as endogenou...
updateTrackers	[UpdateTracker:9782178] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v59:[updateContainedRLE] [UpdateTracker:9846705] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v84:[modifyText] [UpdateTracker:9863962] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v88:[addHasEvent, updateContainedRLE] [UpdateTracker:9776395] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v76:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-168898] Toll-like Receptor Cascades
(hasEncapsulatedEvent)	[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane [Pathway:R-HSA-5620971] Pyroptosis
(normalPathway)	[Pathway:R-HSA-9824856] Defective regulation of TLR7 by endogenous ligand
(updatedInstance)	[UpdateTracker:9782178] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v59:[updateContainedRLE] [UpdateTracker:9846705] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v84:[modifyText] [UpdateTracker:9863962] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v88:[addHasEvent, updateContainedRLE] [UpdateTracker:9776395] Update Tracker - [Pathway:5686938] Regulation of TLR by endogenous ligand - v76:[updateContainedRLE]

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