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Entries
Regulation of TLR by endogenous ligand
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authored
[InstanceEdit:6797423] Shamovsky, Veronica, 2015-09-12
created
[InstanceEdit:5686931] Shamovsky, Veronica, 2015-04-06
dbId
5686938
displayName
Regulation of TLR by endogenous ligand
doi
10.3180/R-HSA-5686938.1
edited
[InstanceEdit:8870483] Shamovsky, Veronica, 2016-05-10
eventOf
[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-6805981] HMGB1 release from cells - Homo sapiens
[Reaction:R-HSA-5432825] HMGB1 binds TLR4:LY96 - Homo sapiens
[Reaction:R-HSA-6804100] HMGB1 binds LPS - Homo sapiens
[Reaction:R-HSA-6804099] HMGB1 binds LTP - Homo sapiens
[Reaction:R-HSA-5432852] SFTPA/SFTPD binds TLR4:LY96 - Homo sapiens
[Reaction:R-HSA-5432814] SFTPA/SFTPD binds TLR2:TLR1 - Homo sapiens
[Reaction:R-HSA-5432849] S100A8:S100A9 binds TLR4:LY96 - Homo sapiens
[Reaction:R-HSA-6805943] S100A1 binds TLR4:LY96 - Homo sapiens
[Reaction:R-HSA-8869694] oxPL binds CD14 - Homo sapiens
[Reaction:R-HSA-8869683] oxPL binds LBP - Homo sapiens
[Reaction:R-HSA-8869667] oxLDL:CD36 binds TLR4:TLR6 - Homo sapiens
[Reaction:R-HSA-8870678] Cleaved fibrinogen products bind TLR4:LY96 - Homo sapiens
[Reaction:R-HSA-9824732] G or G analog binds C-ter TLR7 dimer - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5686934] DAMPening inflammation by modulating TLR signalling
[LiteratureReference:6793749] Endogenous toll-like receptor ligands and their biological significance
[LiteratureReference:6804095] Complexity of danger: the diverse nature of damage-associated molecular patterns
[LiteratureReference:5686936] Endogenous ligands of TLR2 and TLR4: agonists or assistants?
modified
[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name
Regulation of TLR by endogenous ligand
orthologousEvent
[Pathway:R-MMU-5686938] Regulation of TLR by endogenous ligand - Mus musculus
[Pathway:R-BTA-5686938] Regulation of TLR by endogenous ligand - Bos taurus
[Pathway:R-PFA-5686938] Regulation of TLR by endogenous ligand - Plasmodium falciparum
[Pathway:R-SCE-5686938] Regulation of TLR by endogenous ligand - Saccharomyces cerevisiae
[Pathway:R-SPO-5686938] Regulation of TLR by endogenous ligand - Schizosaccharomyces pombe
[Pathway:R-DDI-5686938] Regulation of TLR by endogenous ligand - Dictyostelium discoideum
[Pathway:R-DME-5686938] Regulation of TLR by endogenous ligand - Drosophila melanogaster
[Pathway:R-GGA-5686938] Regulation of TLR by endogenous ligand - Gallus gallus
[Pathway:R-XTR-5686938] Regulation of TLR by endogenous ligand - Xenopus tropicalis
[Pathway:R-DRE-5686938] Regulation of TLR by endogenous ligand - Danio rerio
[Pathway:R-SSC-5686938] Regulation of TLR by endogenous ligand - Sus scrofa
[Pathway:R-CEL-5686938] Regulation of TLR by endogenous ligand - Caenorhabditis elegans
[Pathway:R-CFA-5686938] Regulation of TLR by endogenous ligand - Canis familiaris
[Pathway:R-RNO-5686938] Regulation of TLR by endogenous ligand - Rattus norvegicus
releaseDate
2016-06-15
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:6797517] D'Eustachio, Peter, 2015-09-12
[InstanceEdit:8870806] Granucci, Francesca, Zanoni, Ivan
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5686938
summation
[Summation:5686933] Diverse molecules of host-cell origin may serve as endogenou...
Referrals
(normalPathway)
[Pathway:R-HSA-9824856] Defective regulation of TLR7 by endogenous ligand
(hasEvent)
[Pathway:R-HSA-168898] Toll-like Receptor Cascades
(hasEncapsulatedEvent)
[Pathway:R-HSA-5620971] Pyroptosis
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane
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