Reactome | Toll Like Receptor 4 (TLR4) Cascade

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Toll Like Receptor 4 (TLR4) Cascade Show undefined attributes

authored	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
created	[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
crossReference	[DatabaseIdentifier:12819451] BioModels Database:BIOMD0000000477
dbId	166016
displayName	Toll Like Receptor 4 (TLR4) Cascade
doi	10.3180/REACT_6894.8
edited	[InstanceEdit:1014302] Shamovsky, V, 2010-11-15
eventOf	[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
figure	[Figure:3209985] /figures/Pathway_Illustrations/TLR4_cascade_72_oicr.png
goBiologicalProcess	[GO_BiologicalProcess:259012] toll-like receptor 4 signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-166015] Association of LBP with LPS - Homo sapiens [Pathway:R-HSA-166020] Transfer of LPS from LBP carrier to CD14 - Homo sapiens [Reaction:R-HSA-166041] Transfer of LPS onto TLR4 - Homo sapiens [Reaction:R-HSA-2559439] CD14:LPS binds CR3 - Homo sapiens [Reaction:R-HSA-2201293] Endocytosis of TLR4:LY96:LPS:CD14 - Homo sapiens [Reaction:R-HSA-2201341] Endocytosis of TRAM (TICAM2) - Homo sapiens [Reaction:R-HSA-166168] TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) - Homo sapiens [Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens [Pathway:R-HSA-166166] MyD88-independent TLR4 cascade - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:166158] Endotoxin recognition and signal transduction by the TLR4/MD2-complex [LiteratureReference:2445183] Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins [LiteratureReference:169758] Endotoxin signaling in human macrophages: signaling via an alternate mechanism
maxDepth	8
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Toll Like Receptor 4 (TLR4) Cascade
orthologousEvent	[Pathway:R-MMU-166016] Toll Like Receptor 4 (TLR4) Cascade - Mus musculus [Pathway:R-RNO-166016] Toll Like Receptor 4 (TLR4) Cascade - Rattus norvegicus [Pathway:R-CFA-166016] Toll Like Receptor 4 (TLR4) Cascade - Canis familiaris [Pathway:R-BTA-166016] Toll Like Receptor 4 (TLR4) Cascade - Bos taurus [Pathway:R-SSC-166016] Toll Like Receptor 4 (TLR4) Cascade - Sus scrofa [Pathway:R-DRE-166016] Toll Like Receptor 4 (TLR4) Cascade - Danio rerio [Pathway:R-XTR-166016] Toll Like Receptor 4 (TLR4) Cascade - Xenopus tropicalis [Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade - Gallus gallus [Pathway:R-CEL-166016] Toll Like Receptor 4 (TLR4) Cascade - Caenorhabditis elegans [Pathway:R-SPO-166016] Toll Like Receptor 4 (TLR4) Cascade - Schizosaccharomyces pombe [Pathway:R-SCE-166016] Toll Like Receptor 4 (TLR4) Cascade - Saccharomyces cerevisiae [Pathway:R-DME-166016] Toll Like Receptor 4 (TLR4) Cascade - Drosophila melanogaster [Pathway:R-DDI-166016] Toll Like Receptor 4 (TLR4) Cascade - Dictyostelium discoideum [Pathway:R-PFA-166016] Toll Like Receptor 4 (TLR4) Cascade - Plasmodium falciparum
relatedSpecies	[Species:181384] Chlamydia trachomatis [Species:180800] Neisseria meningitidis serogroup B
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17 [InstanceEdit:1095192] Gillespie, ME, 2010-11-30
revised	[InstanceEdit:2559479] Shamovsky, V, 2012-11-02
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-166016
summation	[Summation:166407] Toll-like Receptor 4 is a microbe associated molecular patte... [Summation:169734] TLR4 is unique among the TLR family in its ability to recrui...
updateTrackers	[UpdateTracker:9790290] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v34:[updateContainedRLE] [UpdateTracker:9782973] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v58:[updateContainedRLE] [UpdateTracker:9788364] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v42:[updateContainedRLE] [UpdateTracker:9864216] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v88:[updateIndirectRLE] [UpdateTracker:9775217] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v80:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9788223] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v43:[add_removeHasEvent, modifyText, updateContainedPathway, updateContainedRLE] [UpdateTracker:9787368] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v45:[updateContainedRLE] [UpdateTracker:9783985] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v55:[updateContainedRLE] [UpdateTracker:9774693] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v81:[updateContainedPathway] [UpdateTracker:9790097] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v35:[updateContainedPathway, updateContainedRLE] [UpdateTracker:9780335] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v63:[addLiteratureReference, addSummation, add_removeHasEvent, modifyText, updateContainedPathway] [UpdateTracker:9788615] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v41:[addHasEvent, updateContainedRLE] [UpdateTracker:9779199] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v66:[updateIndirectRLE] [UpdateTracker:9785523] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v52:[updateContainedRLE] [UpdateTracker:9778656] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v68:[updateContainedPathway] [UpdateTracker:9786639] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v49:[updateContainedRLE] [UpdateTracker:9842223] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v86:[updateContainedPathway]

Referrals

(hasEvent)

[Pathway:R-HSA-168898] Toll-like Receptor Cascades

(updatedInstance)

[UpdateTracker:9790290] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v34:[updateContainedRLE]
[UpdateTracker:9782973] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v58:[updateContainedRLE]
[UpdateTracker:9788364] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v42:[updateContainedRLE]
[UpdateTracker:9864216] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v88:[updateIndirectRLE]
[UpdateTracker:9775217] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v80:[updateContainedPathway, updateContainedRLE]
[UpdateTracker:9788223] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v43:[add_removeHasEvent, modifyText, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9787368] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v45:[updateContainedRLE]
[UpdateTracker:9783985] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v55:[updateContainedRLE]
[UpdateTracker:9774693] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v81:[updateContainedPathway]
[UpdateTracker:9790097] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v35:[updateContainedPathway, updateContainedRLE]
[UpdateTracker:9780335] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v63:[addLiteratureReference, addSummation, add_removeHasEvent, modifyText, updateContainedPathway]
[UpdateTracker:9788615] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v41:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779199] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v66:[updateIndirectRLE]
[UpdateTracker:9785523] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v52:[updateContainedRLE]
[UpdateTracker:9778656] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v68:[updateContainedPathway]
[UpdateTracker:9786639] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v49:[updateContainedRLE]
[UpdateTracker:9842223] Update Tracker - [Pathway:166016] Toll Like Receptor 4 (TLR4) Cascade - v86:[updateContainedPathway]

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