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Schema
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Pathway
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Entries
Toll Like Receptor 4 (TLR4) Cascade
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authored
[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
created
[InstanceEdit:166017] de Bono, B, 2005-08-16 10:54:15
crossReference
[DatabaseIdentifier:12325404] BioModels Database:BIOMD0000000477
dbId
166016
displayName
Toll Like Receptor 4 (TLR4) Cascade
doi
10.3180/REACT_6894.8
edited
[InstanceEdit:1014302] Shamovsky, V, 2010-11-15
eventOf
[Pathway:R-HSA-168898] Toll-like Receptor Cascades - Homo sapiens
figure
[Figure:3209985] /figures/Pathway_Illustrations/TLR4_cascade_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:259012] toll-like receptor 4 signaling pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-166015] Association of LBP with LPS - Homo sapiens
[Pathway:R-HSA-166020] Transfer of LPS from LBP carrier to CD14 - Homo sapiens
[Reaction:R-HSA-166041] Transfer of LPS onto TLR4 - Homo sapiens
[Reaction:R-HSA-2559439] CD14:LPS binds CR3 - Homo sapiens
[Reaction:R-HSA-2201293] Endocytosis of TLR4:LY96:LPS:CD14 - Homo sapiens
[Reaction:R-HSA-2201341] Endocytosis of TRAM (TICAM2) - Homo sapiens
[Reaction:R-HSA-166168] TLR4:LY96:LPS:CD14 recruits TRAM (TICAM2) - Homo sapiens
[Pathway:R-HSA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Homo sapiens
[Pathway:R-HSA-166166] MyD88-independent TLR4 cascade - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:166158] Endotoxin recognition and signal transduction by the TLR4/MD2-complex
[LiteratureReference:2445183] Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins
[LiteratureReference:169758] Endotoxin signaling in human macrophages: signaling via an alternate mechanism
modified
[InstanceEdit:12325341] Wright, Adam, 2024-02-14
name
Toll Like Receptor 4 (TLR4) Cascade
orthologousEvent
[Pathway:R-CEL-166016] Toll Like Receptor 4 (TLR4) Cascade - Caenorhabditis elegans
[Pathway:R-PFA-166016] Toll Like Receptor 4 (TLR4) Cascade - Plasmodium falciparum
[Pathway:R-SCE-166016] Toll Like Receptor 4 (TLR4) Cascade - Saccharomyces cerevisiae
[Pathway:R-SPO-166016] Toll Like Receptor 4 (TLR4) Cascade - Schizosaccharomyces pombe
[Pathway:R-DDI-166016] Toll Like Receptor 4 (TLR4) Cascade - Dictyostelium discoideum
[Pathway:R-DME-166016] Toll Like Receptor 4 (TLR4) Cascade - Drosophila melanogaster
[Pathway:R-XTR-166016] Toll Like Receptor 4 (TLR4) Cascade - Xenopus tropicalis
[Pathway:R-DRE-166016] Toll Like Receptor 4 (TLR4) Cascade - Danio rerio
[Pathway:R-SSC-166016] Toll Like Receptor 4 (TLR4) Cascade - Sus scrofa
[Pathway:R-BTA-166016] Toll Like Receptor 4 (TLR4) Cascade - Bos taurus
[Pathway:R-GGA-166016] Toll Like Receptor 4 (TLR4) Cascade - Gallus gallus
[Pathway:R-MMU-166016] Toll Like Receptor 4 (TLR4) Cascade - Mus musculus
[Pathway:R-RNO-166016] Toll Like Receptor 4 (TLR4) Cascade - Rattus norvegicus
[Pathway:R-CFA-166016] Toll Like Receptor 4 (TLR4) Cascade - Canis familiaris
relatedSpecies
[Species:181384] Chlamydia trachomatis
[Species:180800] Neisseria meningitidis serogroup B
releaseDate
2006-04-24
releaseStatus
UPDATED
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:188961] Gay, NJ, 2006-04-24 16:48:17
[InstanceEdit:1095192] Gillespie, ME, 2010-11-30
revised
[InstanceEdit:2559479] Shamovsky, V, 2012-11-02
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-166016
summation
[Summation:166407] Toll-like Receptor 4 is a microbe associated molecular patte...
[Summation:169734] TLR4 is unique among the TLR family in its ability to recrui...
Referrals
(hasEvent)
[Pathway:R-HSA-168898] Toll-like Receptor Cascades
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