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Entries
Sphingolipid de novo biosynthesis
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authored
[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
compartment
[Compartment:70101] cytosol
[Compartment:17957] endoplasmic reticulum lumen
[Compartment:12045] endoplasmic reticulum membrane
created
[InstanceEdit:1660664] Jassal, B, 2011-10-14
dbId
1660661
displayName
Sphingolipid de novo biosynthesis
edited
[InstanceEdit:1660664] Jassal, B, 2011-10-14
eventOf
[Pathway:R-HSA-428157] Sphingolipid metabolism - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:5277] sphingolipid biosynthetic process
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5693761] FA2H hydroxylates 1,2-saturated fatty acids - Homo sapiens
[Reaction:R-HSA-428127] SPTLC complexes transfer acyl-CoA onto serine - Homo sapiens
[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens
[Reaction:R-HSA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Homo sapiens
[Reaction:R-HSA-428259] DEGS1 dehydrogenates dihydroceramide - Homo sapiens
[Reaction:R-HSA-428260] DEGS2 oxygenates dihydroceramide - Homo sapiens
[Reaction:R-HSA-429698] PRKD1,2,3 phosphorylates CERT1-2 - Homo sapiens
[Reaction:R-HSA-429714] CSNK1G2 phosphorylates p-CERT1-2 - Homo sapiens
[Reaction:R-HSA-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Homo sapiens
[Reaction:R-HSA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Homo sapiens
[Reaction:R-HSA-429798] SGMS1 transfers phosphocholine onto ceramide - Homo sapiens
[Reaction:R-HSA-429786] SGMS2 transfers phosphocholine onto ceramide - Homo sapiens
[Reaction:R-HSA-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER - Homo sapiens
[Reaction:R-HSA-428273] SPHK1 phosphorylates sphingoid - Homo sapiens
[Reaction:R-HSA-9695949] SPHK2 phosphorylates sphingoid - Homo sapiens
[Reaction:R-HSA-9695917] SPHK2 binds SPHK2 inhibitors - Homo sapiens
[Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Homo sapiens
[Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023-09-13
literatureReference
[LiteratureReference:428144] De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway
[LiteratureReference:1660665] An overview of sphingolipid metabolism: from synthesis to breakdown
maxDepth
2
modified
[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name
Sphingolipid de novo biosynthesis
orthologousEvent
[Pathway:R-MMU-1660661] Sphingolipid de novo biosynthesis - Mus musculus
[Pathway:R-RNO-1660661] Sphingolipid de novo biosynthesis - Rattus norvegicus
[Pathway:R-CFA-1660661] Sphingolipid de novo biosynthesis - Canis familiaris
[Pathway:R-BTA-1660661] Sphingolipid de novo biosynthesis - Bos taurus
[Pathway:R-SSC-1660661] Sphingolipid de novo biosynthesis - Sus scrofa
[Pathway:R-DRE-1660661] Sphingolipid de novo biosynthesis - Danio rerio
[Pathway:R-XTR-1660661] Sphingolipid de novo biosynthesis - Xenopus tropicalis
[Pathway:R-GGA-1660661] Sphingolipid de novo biosynthesis - Gallus gallus
[Pathway:R-DME-1660661] Sphingolipid de novo biosynthesis - Drosophila melanogaster
[Pathway:R-CEL-1660661] Sphingolipid de novo biosynthesis - Caenorhabditis elegans
[Pathway:R-DDI-1660661] Sphingolipid de novo biosynthesis - Dictyostelium discoideum
[Pathway:R-SPO-1660661] Sphingolipid de novo biosynthesis - Schizosaccharomyces pombe
[Pathway:R-SCE-1660661] Sphingolipid de novo biosynthesis - Saccharomyces cerevisiae
[Pathway:R-PFA-1660661] Sphingolipid de novo biosynthesis - Plasmodium falciparum
previousReviewStatus
[ReviewStatus:9821385] four stars
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17
[InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
[InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1660661
summation
[Summation:1660666] Glycosphingolipid biosynthesis is based on salvage of sphing...
updateTrackers
[UpdateTracker:9964732] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v94:[add_removeHasEvent]
[UpdateTracker:9782974] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v58:[updateContainedRLE]
[UpdateTracker:9842308] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v86:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9781916] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v60:[addHasEvent]
[UpdateTracker:9780100] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v64:[updateContainedRLE]
[UpdateTracker:9786730] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v48:[updateContainedRLE]
[UpdateTracker:9784277] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v54:[addHasEvent]
[UpdateTracker:9783529] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9775374] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v79:[updateContainedRLE]
[UpdateTracker:9782048] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v59:[updateContainedRLE]
[UpdateTracker:9783255] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v57:[updateContainedRLE]
[UpdateTracker:9783796] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v55:[updateContainedRLE]
[UpdateTracker:9784603] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9776811] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9853192] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v87:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9774705] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v81:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-428157] Sphingolipid metabolism
(updatedInstance)
[UpdateTracker:9964732] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v94:[add_removeHasEvent]
[UpdateTracker:9782974] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v58:[updateContainedRLE]
[UpdateTracker:9842308] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v86:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9781916] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v60:[addHasEvent]
[UpdateTracker:9780100] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v64:[updateContainedRLE]
[UpdateTracker:9786730] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v48:[updateContainedRLE]
[UpdateTracker:9784277] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v54:[addHasEvent]
[UpdateTracker:9783529] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v56:[addHasEvent, updateContainedRLE]
[UpdateTracker:9775374] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v79:[updateContainedRLE]
[UpdateTracker:9782048] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v59:[updateContainedRLE]
[UpdateTracker:9783255] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v57:[updateContainedRLE]
[UpdateTracker:9783796] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v55:[updateContainedRLE]
[UpdateTracker:9784603] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v53:[updateContainedRLE]
[UpdateTracker:9776811] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v74:[addHasEvent, updateContainedRLE]
[UpdateTracker:9853192] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v87:[add_removeHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9774705] Update Tracker - [Pathway:1660661] Sphingolipid de novo biosynthesis - v81:[addHasEvent]
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