Reactome | Sphingolipid metabolism

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Sphingolipid metabolism Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
created	[InstanceEdit:428151] D'Eustachio, P, 2009-07-02
dbId	428157
displayName	Sphingolipid metabolism
doi	10.3180/REACT_19323.1
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-556833] Metabolism of lipids - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5272] sphingolipid metabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens [Pathway:R-HSA-1660662] Glycosphingolipid metabolism - Homo sapiens [Pathway:R-HSA-9845614] Sphingolipid catabolism - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:428160] Principles of bioactive lipid signalling: lessons from sphingolipids [LiteratureReference:428144] De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway [LiteratureReference:429720] Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes [LiteratureReference:9851334] Gangliosides: Structures, Biosynthesis, Analysis, and Roles in Cancer
maxDepth	4
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Sphingolipid metabolism
orthologousEvent	[Pathway:R-MMU-428157] Sphingolipid metabolism - Mus musculus [Pathway:R-RNO-428157] Sphingolipid metabolism - Rattus norvegicus [Pathway:R-CFA-428157] Sphingolipid metabolism - Canis familiaris [Pathway:R-SSC-428157] Sphingolipid metabolism - Sus scrofa [Pathway:R-DRE-428157] Sphingolipid metabolism - Danio rerio [Pathway:R-XTR-428157] Sphingolipid metabolism - Xenopus tropicalis [Pathway:R-GGA-428157] Sphingolipid metabolism - Gallus gallus [Pathway:R-DME-428157] Sphingolipid metabolism - Drosophila melanogaster [Pathway:R-CEL-428157] Sphingolipid metabolism - Caenorhabditis elegans [Pathway:R-SPO-428157] Sphingolipid metabolism - Schizosaccharomyces pombe [Pathway:R-SCE-428157] Sphingolipid metabolism - Saccharomyces cerevisiae [Pathway:R-PFA-428157] Sphingolipid metabolism - Plasmodium falciparum [Pathway:R-BTA-428157] Sphingolipid metabolism - Bos taurus [Pathway:R-DDI-428157] Sphingolipid metabolism - Dictyostelium discoideum
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9842059] D'Eustachio, Peter, 2023-08-17 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-428157
summation	[Summation:428169] Sphingolipids are derivatives of long chain sphingoid bases ...
updateTrackers	[UpdateTracker:9779732] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v64:[updateIndirectRLE] [UpdateTracker:9864199] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v88:[updateIndirectRLE] [UpdateTracker:9776533] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v75:[updateIndirectRLE] [UpdateTracker:9783786] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v55:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782362] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v59:[updateIndirectRLE] [UpdateTracker:9776907] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842264] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v86:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785193] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v52:[updateContainedPathway] [UpdateTracker:9786470] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v49:[updateContainedPathway] [UpdateTracker:9853249] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v87:[addLiteratureReference, add_removeHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9774725] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v81:[updateContainedPathway] [UpdateTracker:9788619] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v41:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787097] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v46:[updateIndirectRLE] [UpdateTracker:9784513] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v54:[updateContainedPathway] [UpdateTracker:9788988] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v39:[add_removeHasEvent] [UpdateTracker:9783501] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v56:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789842] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v37:[updateContainedRLE] [UpdateTracker:9784856] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v53:[updateIndirectRLE] [UpdateTracker:9786826] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v48:[updateIndirectRLE] [UpdateTracker:9775286] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v79:[updateIndirectRLE] [UpdateTracker:9779578] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v65:[updateContainedPathway] [UpdateTracker:9781605] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v60:[updateContainedPathway] [UpdateTracker:9782838] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v58:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783121] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v57:[updateContainedPathway, updateIndirectRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-556833] Metabolism of lipids
(hasEncapsulatedEvent)	[Pathway:R-HSA-9845576] Glycosphingolipid transport [Pathway:R-HSA-373076] Class A/1 (Rhodopsin-like receptors) [Pathway:R-HSA-4085001] Sialic acid metabolism
(updatedInstance)	[UpdateTracker:9779732] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v64:[updateIndirectRLE] [UpdateTracker:9864199] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v88:[updateIndirectRLE] [UpdateTracker:9776533] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v75:[updateIndirectRLE] [UpdateTracker:9783786] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v55:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9782362] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v59:[updateIndirectRLE] [UpdateTracker:9776907] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v74:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9842264] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v86:[addHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9785193] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v52:[updateContainedPathway] [UpdateTracker:9786470] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v49:[updateContainedPathway] [UpdateTracker:9853249] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v87:[addLiteratureReference, add_removeHasEvent, updateContainedPathway, updateIndirectRLE] [UpdateTracker:9774725] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v81:[updateContainedPathway] [UpdateTracker:9788619] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v41:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9787097] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v46:[updateIndirectRLE] [UpdateTracker:9784513] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v54:[updateContainedPathway] [UpdateTracker:9788988] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v39:[add_removeHasEvent] [UpdateTracker:9783501] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v56:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9789842] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v37:[updateContainedRLE] [UpdateTracker:9784856] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v53:[updateIndirectRLE] [UpdateTracker:9786826] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v48:[updateIndirectRLE] [UpdateTracker:9775286] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v79:[updateIndirectRLE] [UpdateTracker:9779578] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v65:[updateContainedPathway] [UpdateTracker:9781605] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v60:[updateContainedPathway] [UpdateTracker:9782838] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v58:[updateContainedPathway, updateIndirectRLE] [UpdateTracker:9783121] Update Tracker - [Pathway:428157] Sphingolipid metabolism - v57:[updateContainedPathway, updateIndirectRLE]

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