Reactome | SPHK2 phosphorylates sphingoid

Schema > Reaction > Entries

SPHK2 phosphorylates sphingoid Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:9695919] lipid kinase activity of SPHK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9695955] Jassal, Bijay, 2020-07-16
dbId	9695949
displayName	SPHK2 phosphorylates sphingoid
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - Homo sapiens [Reaction:R-HSA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Homo sapiens [Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region - Homo sapiens [Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-428682] SPG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:428274] Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform [LiteratureReference:9695942] SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism [LiteratureReference:9843387] Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget [LiteratureReference:9843382] The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	SPHK2 phosphorylates sphingoid
orthologousEvent	[Reaction:R-SCE-9695949] SPHK2 phosphorylates sphingoid - Saccharomyces cerevisiae [Reaction:R-SPO-9695949] SPHK2 phosphorylates sphingoid - Schizosaccharomyces pombe [Reaction:R-DDI-9695949] SPHK2 phosphorylates sphingoid - Dictyostelium discoideum [Reaction:R-CEL-9695949] SPHK2 phosphorylates sphingoid - Caenorhabditis elegans [Reaction:R-DME-9695949] SPHK2 phosphorylates sphingoid - Drosophila melanogaster [Reaction:R-XTR-9695949] SPHK2 phosphorylates sphingoid - Xenopus tropicalis [Reaction:R-SSC-9695949] SPHK2 phosphorylates sphingoid - Sus scrofa [Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid - Bos taurus [Reaction:R-CFA-9695949] SPHK2 phosphorylates sphingoid - Canis familiaris [Reaction:R-RNO-9695949] SPHK2 phosphorylates sphingoid - Rattus norvegicus [Reaction:R-MMU-9695949] SPHK2 phosphorylates sphingoid - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-5279322] S1P [cytoplasm]
precedingEvent	[Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - Homo sapiens [Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens [Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9695921] Negative regulation by 'SPHK2:SPHK2 inhibitors [cytosol]'
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9695949
summation	[Summation:9695948] The cytosolic enzyme sphingosine kinase 2 (SPHK2) catalyzes ...

Referrals

(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-HSA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates [Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region [Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region [Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates [Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

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