Reactome | SGMS2 transfers phosphocholine onto ceramide

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SGMS2 transfers phosphocholine onto ceramide Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429800] sphingomyelin synthase activity of 2xPalmC-SGMS2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:429791] D'Eustachio, P, 2009-07-21
crossReference	[DatabaseIdentifier:12667866] RHEA:81452
dbId	429786
displayName	SGMS2 transfers phosphocholine onto ceramide
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin - Homo sapiens [Reaction:R-HSA-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Homo sapiens
input	[SimpleEntity:R-ALL-429807] CERA [plasma membrane] [SimpleEntity:R-ALL-429802] PC [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429792] Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells [LiteratureReference:429797] Identification of a family of animal sphingomyelin synthases [LiteratureReference:429779] Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes [LiteratureReference:435217] Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells [LiteratureReference:435213] The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver [LiteratureReference:435218] SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis [LiteratureReference:9843208] The sphingomyelin synthase family: proteins, diseases, and inhibitors
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SGMS2 transfers phosphocholine onto ceramide phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS2]
orthologousEvent	[Reaction:R-PFA-429786] SGMS2 transfers phosphocholine onto ceramide - Plasmodium falciparum [Reaction:R-MMU-429786] SGMS2 transfers phosphocholine onto ceramide - Mus musculus [Reaction:R-CEL-429786] SGMS2 transfers phosphocholine onto ceramide - Caenorhabditis elegans [Reaction:R-GGA-429786] SGMS2 transfers phosphocholine onto ceramide - Gallus gallus [Reaction:R-XTR-429786] SGMS2 transfers phosphocholine onto ceramide - Xenopus tropicalis [Reaction:R-DRE-429786] SGMS2 transfers phosphocholine onto ceramide - Danio rerio [Reaction:R-SSC-429786] SGMS2 transfers phosphocholine onto ceramide - Sus scrofa [Reaction:R-BTA-429786] SGMS2 transfers phosphocholine onto ceramide - Bos taurus [Reaction:R-CFA-429786] SGMS2 transfers phosphocholine onto ceramide - Canis familiaris [Reaction:R-RNO-429786] SGMS2 transfers phosphocholine onto ceramide - Rattus norvegicus
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-9843210] SPHM [plasma membrane]
precedingEvent	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin - Homo sapiens [Reaction:R-HSA-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane) - Homo sapiens [Reaction:R-HSA-1861788] GBA2 hydrolyzes GlcCer (plasma membrane) - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429786
summation	[Summation:429790] SGMS2 (sphingomyelin synthase 2) catalyzes the reversible re...
updateTrackers	[UpdateTracker:9853267] Update Tracker - [Reaction:429786] SGMS2 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853267] Update Tracker - [Reaction:429786] SGMS2 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-HSA-1640164] ENPP7 hydrolyzes sphingomyelin [Reaction:R-HSA-1606273] SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)

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