Reactome | SPHK1 phosphorylates sphingoid

Schema > Reaction > Entries

SPHK1 phosphorylates sphingoid Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428281] lipid kinase activity of SPHK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428277] D'Eustachio, P, 2009-07-03
crossReference	[DatabaseIdentifier:12667861] RHEA:51496
dbId	428273
deleted	[Deleted:9949969] Deletion of instance: 428214 [Deleted:9863469] Deletion of instance: 428214
displayName	SPHK1 phosphorylates sphingoid
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - Homo sapiens [Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates - Homo sapiens [Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Homo sapiens [Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region - Homo sapiens [Reaction:R-HSA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-428682] SPG [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:428217] Functional characterization of human sphingosine kinase-1 [LiteratureReference:428279] Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes [LiteratureReference:9843387] Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget [LiteratureReference:9843388] Molecular basis of sphingosine kinase 1 substrate recognition and catalysis [LiteratureReference:9843382] The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism [LiteratureReference:9843381] Transcriptional Regulation of Sphingosine Kinase 1 [LiteratureReference:9843378] Molecular mechanisms of regulation of sphingosine kinase 1 [LiteratureReference:9843391] Sphingosine 1-phosphate as a link between blood coagulation and inflammation
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SPHK1 phosphorylates sphingoid
orthologousEvent	[Reaction:R-MMU-428273] SPHK1 phosphorylates sphingoid - Mus musculus [Reaction:R-RNO-428273] SPHK1 phosphorylates sphingoid - Rattus norvegicus [Reaction:R-CFA-428273] SPHK1 phosphorylates sphingoid - Canis familiaris [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid - Bos taurus [Reaction:R-SSC-428273] SPHK1 phosphorylates sphingoid - Sus scrofa [Reaction:R-XTR-428273] SPHK1 phosphorylates sphingoid - Xenopus tropicalis [Reaction:R-DME-428273] SPHK1 phosphorylates sphingoid - Drosophila melanogaster [Reaction:R-CEL-428273] SPHK1 phosphorylates sphingoid - Caenorhabditis elegans [Reaction:R-DDI-428273] SPHK1 phosphorylates sphingoid - Dictyostelium discoideum [Reaction:R-SPO-428273] SPHK1 phosphorylates sphingoid - Schizosaccharomyces pombe [Reaction:R-SCE-428273] SPHK1 phosphorylates sphingoid - Saccharomyces cerevisiae [Reaction:R-GGA-428273] SPHK1 phosphorylates sphingoid - Gallus gallus [Reaction:R-GGA-433606] sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP - Gallus gallus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-5279322] S1P [cytoplasm]
precedingEvent	[Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate - Homo sapiens [Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens [Reaction:R-HSA-428231] ACER1 hydrolyzes ceramide (endoplasmic reticulum) - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428273
summation	[Summation:428224] The cytosolic enzyme sphingosine kinase 1 (SPHK1) catalyzes ...
updateTrackers	[UpdateTracker:9853258] Update Tracker - [Reaction:428273] SPHK1 phosphorylates sphingoid - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9776882] Update Tracker - [Reaction:428273] SPHK1 phosphorylates SPG to S1P - v74:[modifyText, removeLiteratureReference]

Referrals

(precedingEvent)	[Reaction:R-HSA-428696] PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate [Reaction:R-HSA-428681] PXLP-SGPL1 cleaves sphingoid-1-phosphates [Reaction:R-HSA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region [Reaction:R-HSA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region [Reaction:R-HSA-428664] SGPP1,2 dephosphorylate sphingoid-1-phosphates
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(replacementInstances)	[Deleted:9949969] Deletion of instance: 428214 [Deleted:9863469] Deletion of instance: 428214
(updatedInstance)	[UpdateTracker:9853258] Update Tracker - [Reaction:428273] SPHK1 phosphorylates sphingoid - v87:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText] [UpdateTracker:9776882] Update Tracker - [Reaction:428273] SPHK1 phosphorylates SPG to S1P - v74:[modifyText, removeLiteratureReference]

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