Reactome | SPTLC complexes transfer acyl-CoA onto serine

Schema > Reaction > Entries

SPTLC complexes transfer acyl-CoA onto serine Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428142] serine C-palmitoyltransferase activity of SPTLC complexes [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428151] D'Eustachio, P, 2009-07-02
dbId	428127
displayName	SPTLC complexes transfer acyl-CoA onto serine
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-200736] L-Ser [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:428173] Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase [LiteratureReference:428170] Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis [LiteratureReference:428150] Is the mammalian serine palmitoyltransferase a high-molecular-mass complex? [LiteratureReference:428124] Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques [LiteratureReference:8865585] Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities [LiteratureReference:8865586] Orm family proteins mediate sphingolipid homeostasis [LiteratureReference:8865579] Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control [LiteratureReference:9842989] Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases [LiteratureReference:9842992] Structural, mechanistic and regulatory studies of serine palmitoyltransferase [LiteratureReference:9842987] Orm/ORMDL proteins: Gate guardians and master regulators [LiteratureReference:9842988] ORMDL in metabolic health and disease [LiteratureReference:9842996] Mechanistic enzymology of serine palmitoyltransferase [LiteratureReference:9842986] 1-Deoxysphingolipids Encountered Exogenously and Made de Novo: Dangerous Mysteries inside an Enigma
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	SPTLC complexes transfer acyl-CoA onto serine acyl-CoA + serine => 3-ketosphingoid + CoASH + CO2
orthologousEvent	[Reaction:R-MMU-428127] SPTLC complexes transfer acyl-CoA onto serine - Mus musculus [Reaction:R-RNO-428127] SPTLC complexes transfer acyl-CoA onto serine - Rattus norvegicus [Reaction:R-CFA-428127] SPTLC complexes transfer acyl-CoA onto serine - Canis familiaris [Reaction:R-BTA-428127] SPTLC complexes transfer acyl-CoA onto serine - Bos taurus [Reaction:R-SSC-428127] SPTLC complexes transfer acyl-CoA onto serine - Sus scrofa [Reaction:R-DRE-428127] SPTLC complexes transfer acyl-CoA onto serine - Danio rerio [Reaction:R-XTR-428127] SPTLC complexes transfer acyl-CoA onto serine - Xenopus tropicalis [Reaction:R-GGA-428127] SPTLC complexes transfer acyl-CoA onto serine - Gallus gallus [Reaction:R-DME-428127] SPTLC complexes transfer acyl-CoA onto serine - Drosophila melanogaster [Reaction:R-GGA-433550] palmitoyl-CoA + serine => 3-dehydrosphinganine + CoASH + CO2 - Gallus gallus
output	[SimpleEntity:R-ALL-9841798] 3-ketosphingoid [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:R-HSA-8871237] Negative regulation by 'ORMDL1,2,3 [endoplasmic reticulum membrane]'
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9842094] D'Eustachio, Peter, 2023-08-17 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428127
summation	[Summation:428184] SPTLC (serine palmitoyltransferase) enzyme complexes associa...
updateTrackers	[UpdateTracker:9783060] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v57:[addRegulator, modifyText] [UpdateTracker:9853218] Update Tracker - [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine - v87:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9842225] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v86:[addLiteratureReference, modifyText] [UpdateTracker:9776676] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v74:[add_removeInput]

Referrals

(precedingEvent)	[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(updatedInstance)	[UpdateTracker:9783060] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v57:[addRegulator, modifyText] [UpdateTracker:9853218] Update Tracker - [Reaction:428127] SPTLC complexes transfer acyl-CoA onto serine - v87:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9842225] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v86:[addLiteratureReference, modifyText] [UpdateTracker:9776676] Update Tracker - [Reaction:428127] palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 - v74:[add_removeInput]

Cite Us!