Reactome | SGMS1 transfers phosphocholine onto ceramide

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SGMS1 transfers phosphocholine onto ceramide Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429784] sphingomyelin synthase activity of SGMS1 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane
created	[InstanceEdit:429791] D'Eustachio, P, 2009-07-21
crossReference	[DatabaseIdentifier:12667866] RHEA:81452
dbId	429798
displayName	SGMS1 transfers phosphocholine onto ceramide
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-428270] CERA [Golgi membrane] [SimpleEntity:R-ALL-429785] PC [Golgi membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429792] Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells [LiteratureReference:429778] Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells [LiteratureReference:429797] Identification of a family of animal sphingomyelin synthases [LiteratureReference:435217] Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells [LiteratureReference:435213] The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver [LiteratureReference:9843208] The sphingomyelin synthase family: proteins, diseases, and inhibitors
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	SGMS1 transfers phosphocholine onto ceramide phosphatidylcholine + ceramide <=> sphingomyelin + diacylglycerol [SGMS1]
orthologousEvent	[Reaction:R-PFA-429798] SGMS1 transfers phosphocholine onto ceramide - Plasmodium falciparum [Reaction:R-CEL-429798] SGMS1 transfers phosphocholine onto ceramide - Caenorhabditis elegans [Reaction:R-GGA-429798] SGMS1 transfers phosphocholine onto ceramide - Gallus gallus [Reaction:R-XTR-429798] SGMS1 transfers phosphocholine onto ceramide - Xenopus tropicalis [Reaction:R-DRE-429798] SGMS1 transfers phosphocholine onto ceramide - Danio rerio [Reaction:R-SSC-429798] SGMS1 transfers phosphocholine onto ceramide - Sus scrofa [Reaction:R-BTA-429798] SGMS1 transfers phosphocholine onto ceramide - Bos taurus [Reaction:R-CFA-429798] SGMS1 transfers phosphocholine onto ceramide - Canis familiaris [Reaction:R-RNO-429798] SGMS1 transfers phosphocholine onto ceramide - Rattus norvegicus [Reaction:R-MMU-429798] SGMS1 transfers phosphocholine onto ceramide - Mus musculus
output	[SimpleEntity:R-ALL-1524057] DAG [Golgi membrane] [SimpleEntity:R-ALL-429789] SPHM [Golgi membrane]
precedingEvent	[Reaction:R-HSA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429798
summation	[Summation:429803] SGMS1 (sphingomyelin synthase 1) associated with the membran...
updateTrackers	[UpdateTracker:9853202] Update Tracker - [Reaction:429798] SGMS1 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9853202] Update Tracker - [Reaction:429798] SGMS1 transfers phosphocholine onto ceramide - v87:[addLiteratureReference, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis

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