Reactome | Ceramide synthases transfer acyl-CoA onto sphingoid

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Ceramide synthases transfer acyl-CoA onto sphingoid Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:428183] sphingosine N-acyltransferase activity of Ceramide synthases [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:428151] D'Eustachio, P, 2009-07-02
dbId	428185
displayName	Ceramide synthases transfer acyl-CoA onto sphingoid
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-428260] DEGS2 oxygenates dihydroceramide - Homo sapiens [Reaction:R-HSA-428259] DEGS1 dehydrogenates dihydroceramide - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-5279323] sphingoid base [cytoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:428188] When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis [LiteratureReference:428148] LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor [LiteratureReference:428130] Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate [LiteratureReference:9843102] Ceramide synthases at the centre of sphingolipid metabolism and biology [LiteratureReference:9843082] Ceramide synthases in biomedical research [LiteratureReference:9843087] Ceramide synthases: roles in cell physiology and signaling [LiteratureReference:9843093] The ceramide synthase (CERS/LASS) family: Functions involved in cancer progression [LiteratureReference:9843083] Ceramide synthases in cancer therapy and chemoresistance [LiteratureReference:9843075] The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases [LiteratureReference:9843099] Impairment of ceramide synthesis causes a novel progressive myoclonus epilepsy [LiteratureReference:9843084] Mutations in CERS3 cause autosomal recessive congenital ichthyosis in humans
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Ceramide synthases transfer acyl-CoA onto sphingoid sphingoid + acyl-CoA => dihydroceramide + CoASH
orthologousEvent	[Reaction:R-MMU-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Mus musculus [Reaction:R-RNO-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Rattus norvegicus [Reaction:R-CFA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Canis familiaris [Reaction:R-BTA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Bos taurus [Reaction:R-SSC-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Sus scrofa [Reaction:R-DRE-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Danio rerio [Reaction:R-XTR-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Xenopus tropicalis [Reaction:R-GGA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Gallus gallus [Reaction:R-DME-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Drosophila melanogaster [Reaction:R-CEL-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Caenorhabditis elegans [Reaction:R-DDI-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Dictyostelium discoideum [Reaction:R-SPO-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Schizosaccharomyces pombe [Reaction:R-SCE-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Saccharomyces cerevisiae [Reaction:R-PFA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Plasmodium falciparum [Reaction:R-GGA-433592] sphinganine + stearyl-CoA => dihydroceramide + CoASH - Gallus gallus
output	[SimpleEntity:R-ALL-76194] CoA-SH [cytosol] [SimpleEntity:R-ALL-428126] DHCE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-428123] KDSR reduces 3-ketosphingoid - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-428185
summation	[Summation:428172] Ceramide synthase enzymes (CerS, LASS) associated with the e...
updateTrackers	[UpdateTracker:9783902] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v55:[modifyText] [UpdateTracker:9789638] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v37:[modifyText] [UpdateTracker:9853253] Update Tracker - [Reaction:428185] Ceramide synthases transfer acyl-CoA onto sphingoid - v87:[addLiteratureReference, addOutput, add_removeInput, modifyText] [UpdateTracker:9784741] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v53:[modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-428260] DEGS2 oxygenates dihydroceramide [Reaction:R-HSA-428259] DEGS1 dehydrogenates dihydroceramide
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(updatedInstance)	[UpdateTracker:9783902] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v55:[modifyText] [UpdateTracker:9789638] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v37:[modifyText] [UpdateTracker:9853253] Update Tracker - [Reaction:428185] Ceramide synthases transfer acyl-CoA onto sphingoid - v87:[addLiteratureReference, addOutput, add_removeInput, modifyText] [UpdateTracker:9784741] Update Tracker - [Reaction:428185] sphinganine + stearyl-CoA => dihydroceramide + CoASH - v53:[modifyText]

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