Reactome | PPM1L dephosphorylates multiphospho-CERT1-2

Schema > Reaction > Entries

PPM1L dephosphorylates multiphospho-CERT1-2 Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429724] protein serine/threonine phosphatase activity of p-S,S132,T-CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:429733] D'Eustachio, P, 2009-07-20
dbId	429730
displayName	PPM1L dephosphorylates multiphospho-CERT1-2
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-429699] CERT1-2 complex binds ceramide - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-429726] p-S,S132,T-CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429720] Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes [LiteratureReference:9843187] Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	PPM1L dephosphorylates multiphospho-CERT1-2 multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate
orthologousEvent	[Reaction:R-DME-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Drosophila melanogaster [Reaction:R-DRE-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Danio rerio [Reaction:R-BTA-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Bos taurus
output	[Complex:R-HSA-429672] CERT1-2:PPM1L:VAPA/B trimer [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-429732] Multiphospho-CERT1-2 binds PPM1L, VAPA/B - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429730
summation	[Summation:429731] PPM1L (protein phosphatase 1-like) catalyzes the dephosphory...

Referrals

(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-HSA-429699] CERT1-2 complex binds ceramide

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