Reactome | PPM1L dephosphorylates multiphospho-CERT1-2

Schema > Reaction > Entries

PPM1L dephosphorylates multiphospho-CERT1-2 Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429724] protein serine/threonine phosphatase activity of PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:429733] D'Eustachio, P, 2009-07-20
crossReference	[DatabaseIdentifier:9857130] RHEA:20630 [DatabaseIdentifier:9857132] RHEA:47005
dbId	429730
deleted	[Deleted:9956922] Deletion of instance: 429732
displayName	PPM1L dephosphorylates multiphospho-CERT1-2
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [EntityWithAccessionedSequence:R-HSA-429695] p-S,S132,T-CERT1-2 [cytosol] [Complex:R-HSA-429703] PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429720] Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes [LiteratureReference:9843187] Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PPM1L dephosphorylates multiphospho-CERT1-2 O-phospho-L-seryl/threonyl-(protein) + H2O => L-seryl/threonyl-(protein) + phosphate
orthologousEvent	[Reaction:R-DME-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Drosophila melanogaster [Reaction:R-DRE-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Danio rerio [Reaction:R-BTA-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Bos taurus
output	[Complex:R-HSA-429672] CERT1-2:PPM1L:VAPA/B dimer [endoplasmic reticulum membrane] 3 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24 [InstanceEdit:9963235] Hill, David P, 2025-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429730
summation	[Summation:429731] Multiphospho-CERT (ceramide transfer protein) associates wit...
updateTrackers	[UpdateTracker:9784701] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v53:[modifyText] [UpdateTracker:9783252] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v57:[modifyText] [UpdateTracker:9853288] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v87:[addLiteratureReference, modifyText] [UpdateTracker:9782047] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v59:[modifyText] [UpdateTracker:9964728] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v94:[add_removeInput, modifyText] [UpdateTracker:9789686] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v37:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9784701] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v53:[modifyText] [UpdateTracker:9783252] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v57:[modifyText] [UpdateTracker:9853288] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v87:[addLiteratureReference, modifyText] [UpdateTracker:9782047] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v59:[modifyText] [UpdateTracker:9964728] Update Tracker - [Reaction:429730] PPM1L dephosphorylates multiphospho-CERT1-2 - v94:[add_removeInput, modifyText] [UpdateTracker:9789686] Update Tracker - [Reaction:429730] multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate - v37:[modifyText]
(replacementInstances)	[Deleted:9956922] Deletion of instance: 429732
(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-HSA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane

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