Reactome | CSNK1G2 phosphorylates p-CERT1-2

Schema > Reaction > Entries

CSNK1G2 phosphorylates p-CERT1-2 Show undefined attributes

authored	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
catalystActivity	[CatalystActivity:429721] protein serine/threonine kinase activity of CSNK1G2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:429702] D'Eustachio, P, 2009-07-18
dbId	429714
displayName	CSNK1G2 phosphorylates p-CERT1-2
edited	[InstanceEdit:433041] D'Eustachio, P, 2009-08-20
eventOf	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-429732] Multiphospho-CERT1-2 binds PPM1L, VAPA/B - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-429704] p-S132-CERT1-2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429709] Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin [LiteratureReference:9843187] Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	CSNK1G2 phosphorylates p-CERT1-2 monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP
orthologousEvent	[Reaction:R-PFA-429714] CSNK1G2 phosphorylates p-CERT1-2 - Plasmodium falciparum [Reaction:R-CEL-429714] CSNK1G2 phosphorylates p-CERT1-2 - Caenorhabditis elegans [Reaction:R-DME-429714] CSNK1G2 phosphorylates p-CERT1-2 - Drosophila melanogaster [Reaction:R-DRE-429714] CSNK1G2 phosphorylates p-CERT1-2 - Danio rerio [Reaction:R-BTA-429714] CSNK1G2 phosphorylates p-CERT1-2 - Bos taurus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [EntityWithAccessionedSequence:R-HSA-429695] p-S,S132,T-CERT1-2 [cytosol]
precedingEvent	[Reaction:R-HSA-429698] PRKD1,2,3 phosphorylates CERT1-2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446905] Hannun, YA, Luberto, C, 2009-11-18 [InstanceEdit:433039] Jassal, B, 2009-08-20 [InstanceEdit:9851344] D'Eustachio, Peter, 2023-10-24 [InstanceEdit:9863708] D'Eustachio, Peter, 2024-03-04
revised	[InstanceEdit:9851456] D'Eustachio, Peter, 2023-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-429714
summation	[Summation:429701] Cytosolic CSNK1G2 (casein kinase 1, gamma 2) catalyzes the p...

Referrals

(hasEvent)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis
(precedingEvent)	[Reaction:R-HSA-429732] Multiphospho-CERT1-2 binds PPM1L, VAPA/B