Reactome | Sphingolipid de novo biosynthesis

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Sphingolipid de novo biosynthesis Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10444606
displayName	Sphingolipid de novo biosynthesis
eventOf	[Pathway:R-BTA-428157] Sphingolipid metabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5277] sphingolipid biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-BTA-5693761] FA2H hydroxylates 1,2-saturated fatty acids - Bos taurus [Reaction:R-BTA-428127] SPTLC complexes transfer acyl-CoA onto serine - Bos taurus [Reaction:R-BTA-428123] KDSR reduces 3-ketosphingoid - Bos taurus [Reaction:R-BTA-428185] Ceramide synthases transfer acyl-CoA onto sphingoid - Bos taurus [Reaction:R-BTA-428259] DEGS1 dehydrogenates dihydroceramide - Bos taurus [Reaction:R-BTA-428260] DEGS2 oxygenates dihydroceramide - Bos taurus [Reaction:R-BTA-429698] PRKD1,2,3 phosphorylates CERT1-2 - Bos taurus [Reaction:R-BTA-429714] CSNK1G2 phosphorylates p-CERT1-2 - Bos taurus [Reaction:R-BTA-429730] PPM1L dephosphorylates multiphospho-CERT1-2 - Bos taurus [Reaction:R-BTA-9956909] CERT1-2 transfers CERA from the ER membrane to the Golgi membrane - Bos taurus [Reaction:R-BTA-429798] SGMS1 transfers phosphocholine onto ceramide - Bos taurus [Reaction:R-BTA-429786] SGMS2 transfers phosphocholine onto ceramide - Bos taurus [Reaction:R-BTA-8959462] SAMD8 transfers phosphatidyl from PE onto C16DH CER - Bos taurus [Reaction:R-BTA-428273] SPHK1 phosphorylates sphingoid - Bos taurus [Reaction:R-BTA-9695949] SPHK2 phosphorylates sphingoid - Bos taurus [Reaction:R-BTA-9695917] SPHK2 binds SPHK2 inhibitors - Bos taurus [Reaction:R-BTA-9695890] SPNS2,MFSD2B transport S1P from cytosol to extracellular region - Bos taurus [Reaction:R-BTA-9843721] ABCC1,ABCG2 transport C18-S1P to extracellular region - Bos taurus
inferredFrom	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Sphingolipid de novo biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48898] Bos taurus
stId	R-BTA-1660661
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-428157] Sphingolipid metabolism
(inferredTo)	[Pathway:R-HSA-1660661] Sphingolipid de novo biosynthesis

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